Journal ArticleDOI
Skeletal blood flow in Paget's disease of bone and its response to calcitonin therapy.
TLDR
There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase, and Glomerular filtration rate appeared to increase transiently in response to calciton in patients re-studied.Abstract:
1. Blood flow to the skeleton was measured by the 18F clearance method of Wooton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxy-proline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.read more
Citations
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Journal ArticleDOI
Paget's Disease of Bone
TL;DR: Progress in Paget's disease research includes new data regarding the etiology of this disorder and the ongoing development of more effective therapies, and the availability of several potent bisphosphonate compounds that produce normal or near normal bone turnover indices in a majority of patients.
Journal ArticleDOI
Radiologic case study
TL;DR: Douleur persistante de la cheville chez un sujet de 36 ans, 6 semaines apres une chute; radiologies standards normales; mise en evidence sur les tomographies et a la R.M.I., d'une fracture osteochondrale du dome du talon.
Journal ArticleDOI
Human and rat α-CGRP but not calcitonin cause mesenteric vasodilatation in rats
TL;DR: It is shown that human and rat α-CGRP are potent vasodilators in the mesenteric vasculature, an effect not mimicked by the alternative gene product, the plasma calcium lowering hormone calcitonin.
Journal ArticleDOI
Skeletal Blood Flow, Iliac Histomorphometry, and Strontium Kinetics in Osteoporosis: A Relationship Between Blood Flow and Corrected Apposition Rate
J. Reeve,Monique E. Arlot,Richard Wootton,C. Edouard,M. Tellez,R. Hesp,J.R. Green,P. J. Meunier +7 more
TL;DR: In 20 untreated patients with idiopathic or postmenopausal osteoporosis, kinetic studies of skeletal blood flow and bone turnover were combined with dynamic histomorphometry performed on transiliac biopsies taken within 6 weeks of each other, finding correlations with indices related to bone turnover at the level of the skeleton as a whole were statistically significant.
Journal ArticleDOI
The single-passage extraction of 18F in rabbit bone.
R Wootton,C Dore +1 more
TL;DR: A novel technique has been developed in which isotope recirculation cannot occur and the post mortem uptake of isotope from surrounding tissues and the vascular tracer content of the bone can be monitored.
References
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On a Form of Chronic Inflammation of Bones (Osteitis Deformans).
TL;DR: The patient on whom the surgeon was able to study was a gentleman of good family, whose parents and grandparents lived to old age with apparently sound health, and among whose relatives no disease was known to have prevailed.
Journal Article
Glomerular filtration rate measurement in man by the single injection methods using 51Cr-EDTA.
Journal ArticleDOI
A simplified heat-inactivation method for investigating alkaline phosphatase isoenzymes in serum.
D.W. Moss,L.G. Whitby +1 more
TL;DR: This method has the advantage of taking into account quantitative variations in the heat stability characteristics of liver alkaline phosphatase from one sample to another, in contrast to methods in which only a single period of exposure to 56 degrees C is employed.
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Heart failure and bone blood flow in osteitis deformans.
Edholm Og,Howarth S,J McMICHAEL +2 more
Journal ArticleDOI
Immediate Effect of Osteotomy on the Intramedullary Pressure of the Femoral Head and Neck in Patients with Degenerative Osteoarthritis
TL;DR: The effect upon intramedullary pressure of two operative procedures routinely performed for painful conditions in osteoarthritis of the hip, osteotomy and Smith Petersen cup, was investigated.