Journal ArticleDOI
Sleep, the hypothalamic–pituitary–adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders
TLDR
Findings suggest that the HPA axis stimulates arousal, while IL-6 and TNF-alpha are possible mediators of excessive daytime sleepiness in humans.About:
This article is published in Endocrinology and Metabolism Clinics of North America.The article was published on 2002-03-01. It has received 344 citations till now. The article focuses on the topics: Excessive daytime sleepiness & Sleep deprivation.read more
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Stress and disorders of the stress system
TL;DR: Optimal basal activity and responsiveness of the stress system is essential for a sense of well-being, successful performance of tasks, and appropriate social interactions, which might impair development, growth and body composition, and lead to a host of behavioral and somatic pathological conditions.
Journal ArticleDOI
The hyperarousal model of insomnia: A review of the concept and its evidence
Dieter Riemann,Kai Spiegelhalder,Bernd Feige,Ulrich Voderholzer,Mathias Berger,Michael L. Perlis,Christoph Nissen +6 more
TL;DR: In this article, a review provides substantial support for the concept that hyperarousal processes from the molecular to the higher system level play a key role in the pathophysiology of primary insomnia.
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Metabolic syndrome: definitions and controversies
TL;DR: It is suggested that diagnosis, prevention and treatment in children and adolescents should better focus on established risk factors rather than the diagnosis of MetS, because of its alarmingly increasing prevalence.
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Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial
Stephen K. Tyring,Alice B. Gottlieb,Kim A. Papp,Kenneth B. Gordon,Craig L. Leonardi,Andrea Wang,Deepa Lalla,Michael Woolley,Angelika Jahreis,Ralph Zitnik,David Cella,Ranga Krishnan +11 more
TL;DR: Improvements in fatigue were correlated with decreasing joint pain, whereas improvements in symptoms of depression were less correlated with objective measures of skin clearance or joint pain.
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Burnout and risk of cardiovascular disease : Evidence, possible causal paths, and promising research directions
TL;DR: Evidence supporting several potential mechanisms linking burnout with ill health, including the metabolic syndrome, dysregulation of the hypothalamic-pituitary-adrenal axis along with sympathetic nervous system activation, sleep disturbances, systemic inflammation, impaired immunity functions, blood coagulation and fibrinolysis, and poor health behaviors is presented.
References
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The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
TL;DR: The main components of the stress system are the corticotropin-releasing hormone and locus ceruleus-norepinephrine/autonomic systems and their peripheral effectors, the pituitary-adrenal axis, and the limbs of the autonomic system as discussed by the authors.
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Epidemiologic study of sleep disturbances and psychiatric disorders : an opportunity for prevention
TL;DR: As part of the National Institute of Mental Health Epidemiologic Catchment Area study, 7954 respondents were questioned at baseline and 1 year later about sleep complaints and psychiatric symptoms using the Diagnostic Interview Schedule.
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The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
TL;DR: Celsus described four of the five cardinal signs of inflammation 2000 years ago, and Eustachio discovered the adrenal glands almost 500 years ago; but not until 1936 did Selye note that in rats exposed to stressors, the adrenAL glands were enlarged, and the thymus and lymph nodes shrunken.