Journal ArticleDOI
Spinning Quarter-Wave Plate Polarization Modulator: Test of Feasibility for Vibrational Circular Dichroism Measurements
Petr Malon,Timothy A. Keiderling +1 more
TLDR
In this article, a rotating quarter-wave plate was used to measure VCD with a step-scan FT-IR spectrometer by incorporating a stressed ZnSe optical element as the rotating quarterwave plate.Abstract:
A novel polarization modulator design based on a rotating quarter-wave plate and preliminary results of its application for vibrational circular dichroism (VCD) are presented. The device permits quarter-wave retardation in the infrared with alternating senses so that the resultant components of circular polarization can be modulated at frequencies on the order of 100 Hz. We have been able to apply this device to measure VCD with a step-scan FT-IR spectrometer by incorporating a stressed ZnSe optical element as the rotating quarter-wave plate. VCD of α-pinene and camphor were obtained. While these test spectra were of low signal-to-noise ratio (S/N), they exhibited the correct VCD spectral features for these chiral molecules. While not yet of competitive, practical utility, this design is potentially adaptable to extension into the far-IR with alternative optical elements, permits variable-frequency polarization modulation, and should be capable of improved S/N with modifications to increase rotation frequency.read more
Citations
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Journal ArticleDOI
INFRARED AND RAMAN VIBRATIONAL OPTICAL ACTIVITY: Theoretical and Experimental Aspects
TL;DR: Applications of VOA now include all major classes of biological and pharmaceutical molecules, and its importance as a diagnostic tool will likely grow as the control of molecular chirality increases in research and industrial areas.
Journal ArticleDOI
Ab Initio Prediction of Vibrational Absorption and Circular Dichroism Spectra of Chiral Natural Products Using Density Functional Theory: Camphor and Fenchone
TL;DR: In this article, density functional theory was used to analyze the vibrational unpolarized absorption and circular dichroism spectra of α-pinene, and the results showed that the accuracy of the Hartree−Fock/self-consistent field (HF/SCF) methodology is markedly inferior to that of DFT.
Journal ArticleDOI
Dual polarization modulation: A real-time, spectral-multiplex separation of circular dichroism from linear birefringence spectral intensities
TL;DR: In this paper, a dual polarization modulation (DPM) method for the complete separation of circular dichroism spectra from linear birefringence (LB) spectra is presented.
Book ChapterDOI
Vibrational Circular Dichroism Spectroscopy of Chiral Molecules
Guochun Yang,Yunjie Xu +1 more
TL;DR: The purpose of this chapter is to provide an up-to-date perspective on the capability of VCD to solve significant problems about chiral molecules in solution, in thin film states, or on surfaces.
Book ChapterDOI
Unfolded peptides and proteins studied with infrared absorption and vibrational circular dichroism spectra.
Timothy A. Keiderling,Qi Xu +1 more
TL;DR: This chapter addresses unfolded protein studies with optical spectroscopy, focusing on vibrational infrared (IR) absorption Spectroscopy and its chiroptical variant, and vibrational circular dichroism (VCD).
References
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Book ChapterDOI
Fourier Transform Infrared Spectroscopy
TL;DR: In this article, the authors describe the common liquid sampling accessories and applications of solution state FTIR spectroscopy to lignins, and the reader is referred to Chapter 4.1.
Journal ArticleDOI
Polarised interferometric spectrometry for the millimetre and submillimetre spectrum
D.H. Martin,E. Puplett +1 more
TL;DR: In this paper, a method of interferometric spectrometry based on polarising beam-splitters is described, which allows operation over a wide range of spectral frequency without strong variations in efficiency, and also the suppression of the mean-level of the interferogram.
Journal ArticleDOI
Piezo-Optical Birefringence Modulators: New Use for a Long-Known Effect
TL;DR: In this article, a general description of a long-neglected use for the piezo-optic or photoelastic effect (stress-induced birefringence) is given, which can be used in a variety of ways, notably to produce a beam of alternately left and right-circularly polarized light for circular-dichroism measurements.
Journal ArticleDOI
Vibrational circular dichroism
Journal ArticleDOI
Vibrational Circular Dichroism
TL;DR: In this article, the observable optical activity can be viewed to have a first-order dependence on the molecular asymmetry and geometrical arrangement and interaction of the atoms in a molecule.
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A solution to the artifact problem in Fourier transform vibrational circular dichroism
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