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Journal ArticleDOI

Spreading depression of activity in the cerebral cortex

Aristides A. P. Leao
- 01 Nov 1944 - 
- Vol. 7, Iss: 6, pp 359-390
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TLDR
In this article, an interesting response elicited by electrical stimulation was noticed in the cortex of rabbits, and the distinctive feature of this response was a marked, enduring reduction of the "spontaneous" electrical activity of the cortex.
Abstract
THIS STUDY originated in an attempt to secure more data for the understanding of the cortical electrogram which occurs in “experimental epilepsy,” and of the conditions in which it is brought forth by electrical stimulation. Early in the development of the study an interesting response, elicited by electrical stimulation, was noticed in the cortex of rabbits. The distinctive feature of this response was a marked, enduring reduction of the “spontaneous” electrical activity of the cortex. We have endeavored to define experimentally some of the characteristics of this response.

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Citations
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Migraine--current understanding and treatment.

TL;DR: The epidemiology, pathophysiology, and preventive and symptomatic treatment of migraine is described, with special attention to drug therapy with the triptans.
Journal ArticleDOI

Mechanisms of migraine aura revealed by functional MRI in human visual cortex

TL;DR: High-field functional MRI with near-continuous recording during visual aura in three subjects observed blood oxygenation level-dependent signal changes that strongly suggest that an electrophysiological event such as CSD generates the aura in human visual cortex.
Journal ArticleDOI

Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis.

TL;DR: The hypothesis predicts that loss of cellular calcium ho­ meostasis underlies selective neuronal vulnerability in ischemia, hypoglycemia, and epileptic seizures and that some cells are more vulner­ able than others because they have a higher density of calcium channels in their plasma membranes.
Journal ArticleDOI

International Classification of Headache Disorders

Jes Olesen
- 01 May 2018 - 
TL;DR: The ICHD identifies and categorizes more than a hundred different kinds of headache in a logical, hierarchal system and has provided explicit diagnostic criteria for all of the headache disorders listed.
References
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Journal ArticleDOI

A study of thalamo-cortical relations

TL;DR: A topographical analysis of thalamo-cortical relations as revealed by alterations in the electrocorticogram induced by localized thalamic stimulation is presented, based upon the assumption that the complex spontaneous pattern of the cortex represents an aggregation of various sorts of activity.
Journal ArticleDOI

Afferent discharges to the cerebral cortex from peripheral sense organs.

TL;DR: The present work has merely confirmed what has been done already, but the recording of nerve impulses as well as cortical potentials can add some details to the picture of events taking place in the brain, and in existing circumstances it seemed advisable to publish what had been done.
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