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Open AccessJournal ArticleDOI

State of the art of nanocrystals--special features, production, nanotoxicology aspects and intracellular delivery

Rainer H. Müller, +4 more
- 01 May 2011 - 
- Vol. 78, Iss: 1, pp 1-9
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TLDR
Drug nanocrystals are the latest, broadly introduced nanoparticulate carrier to the pharmaceutical market from the year 2000 onwards and the effect of size, degradability versus biopersistency and intracellular uptake are discussed, classifying the nanocry crystals in the low/non-risk group.
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This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2011-05-01 and is currently open access. It has received 559 citations till now.

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Citations
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Journal ArticleDOI

Hair follicle targeting with curcumin nanocrystals: Influence of the formulation properties on the penetration efficacy.

Olga Pelikh, +3 more
- 10 Jan 2021 - 
TL;DR: Data so far, suggest that hair follicle targeting with nanocrystals that are suspended in water or simple, shear-thinning gels is highly effective, however, the addition of other excipients, e.g. humectants, to these vehicles might cause changes in the penetration profiles.
Journal ArticleDOI

Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs

Alejandro Javier Paredes, +12 more
- 01 Jan 2021 - 
TL;DR: The ability of microarray patches to deliver poorly soluble actives is highlighted, the mechanisms behind in‐skin drug absorption are discussed, and the future direction of the field is evaluated.
Journal ArticleDOI

Are high drug loading nanoparticles the next step forward for chemotherapy

Joseph Della Rocca, +2 more
- 02 Mar 2012 - 
TL;DR: There exists an acute need to identify a method to make small molecule drugs more bioavailable, protect biologics from premature degradation, and increase tumor uptake of the agent while minimizing nonspecific uptake.
Book ChapterDOI

Xylan, a Promising Hemicellulose for Pharmaceutical Use

Acarília Eduardo da Silva, +5 more
TL;DR: In the pharmaceutical industry, both natural and synthetic polymers have been largely used with different applications for the development and production of cosmetics and traditional dosage forms and novel drug delivery systems.
Journal ArticleDOI

Development of a new method to assess nanocrystal dissolution based on light scattering.

Katharina Anhalt, +6 more
- 12 Jun 2012 - 
TL;DR: A noninvasive, sensitive and reproducible method is presented to assess nanocrystal dissolution based on light scattering to allow a straightforward experimental setup with high temporal resolution.
References
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Journal ArticleDOI

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Gordon L. Amidon, +3 more
- 01 Mar 1995 - 
TL;DR: A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling rate and extent of drug absorption.
Journal ArticleDOI

Nanosuspensions in drug delivery

Barrett E. Rabinow
- 01 Sep 2004 - 
TL;DR: Water insolubility issues of the past have provoked a paradigm change, which now offers novel solutions for innovative drugs of the future, and additional pharmacokinetic benefits of the drugs so formulated have come to be appreciated.
Journal ArticleDOI

Nanosizing: a formulation approach for poorly-water-soluble compounds.

Elaine Merisko-Liversidge, +2 more
- 01 Feb 2003 - 
TL;DR: NanoCrystal Technology is an attrition process wherein large micron size drug crystals are media milled in a water-based stabilizer solution and the process generates physically stable dispersions consisting of nanometer-sized drug crystals.
Patent

Surface modified drug nanoparticles

Liversidge Gary G, +3 more
TL;DR: In this article, the authors describe methods for the preparation of such particles and dispersions containing the particles and demonstrate that such particles exhibit unexpected bioavailability and are useful in methods of treating mammals.
Journal ArticleDOI

Cyclodextrins in drug delivery: an updated review.

Rajeswari Challa, +3 more
- 14 Oct 2005 - 
TL;DR: Cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems associated with the delivery of different novel drugs through different delivery routes.
Related Papers (5)

Nanosuspensions in drug delivery

Barrett E. Rabinow
- 01 Sep 2004 - 

Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation

Cornelia M. Keck, +1 more
- 01 Jan 2006 - 

Nanocrystal technology, drug delivery and clinical applications

Jens-Uwe A. H. Junghanns, +1 more
- 12 Sep 2008 - 

Nanosizing: a formulation approach for poorly-water-soluble compounds.

Elaine Merisko-Liversidge, +2 more
- 01 Feb 2003 - 

Nanosizing--oral formulation development and biopharmaceutical evaluation.

Filippos Kesisoglou, +2 more
- 30 Jul 2007 - 
Frequently Asked Questions (1)
Q1. What are the contributions in this paper?

Drug nanocrystals are the latest, broadly introduced nanoparticulate carrier to the pharmaceutical market from the year 2000 onwards. As nanotoxicological aspects, the effect of size, degradability versus biopersistency and intracellular uptake are discussed, classifying the nanocrystals in the low/non-risk group.