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Stereocontrolled total synthesis of (.+-.)-saframycin B
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This article is published in Journal of the American Chemical Society.The article was published on 1982-09-01. It has received 68 citations till now. The article focuses on the topics: Total synthesis.read more
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Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics.
Journal ArticleDOI
Cyclizations of N-acyliminium ions.
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Intramolecular reactions of N-acyliminium intermediates
W.N. Speckamp,Henk Hiemstra +1 more
TL;DR: Generation des ions Nacyliminiums and syntheses de leurs precurseurs; amidoalkylations intramoleculaires avec des π-nucleophiles aromatiques; reactions de π nucleophilia non aromatique; utilisation des composes a methylene actif; reactions pericycliques
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Enantioselective Total Synthesis of Ecteinascidin 743
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Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem
Carmen Cuevas,Andrés Francesch +1 more
TL;DR: Ecteinascidins are marine natural products consisting of two or three linked tetrahydroisoquinoline subunits and an active carbinolamine functional group that make them attractive candidates for development as anticancer agents.