Journal ArticleDOI
Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
Kenneth L. Rinehart,Tom G. Holt,N. L. Fregeau,Justin G. Stroh,Paul A. Keifer,Furong Sun,Li H. Li,David G. Martin +7 more
TLDR
Ecteinascidins 729, 743, 745, 759A,759B, and 770, tris(tetrahydroisoquinolines) with potent in vivo antitumor activity, have been isolated from the colonial tunicate EctEinascidia turbinata, and their structures have been assigned.Abstract:
Ecteinascidins 729, 743, 745, 759A, 759B, and 770, tris(tetrahydroisoquinolines) with potent in vivo antitumor activity, have been isolated from the colonial tunicate Ecteinascidia turbinata, and their structures have been assignedread more
Citations
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Cascade reactions in total synthesis.
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.
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Biology of mangroves and mangrove Ecosystems
TL;DR: Mangroves are woody plants that grow at the interface between land and sea in tropical and sub-tropical latitudes where they exist in conditions of high salinity, extreme tides, strong winds, high temperatures and muddy, anaerobic soils, creating unique ecological environments that host rich assemblages of species.
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The influence of natural products upon drug discovery.
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A historical overview of natural products in drug discovery.
TL;DR: A review of historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery, and a discussion of how natural product chemistry has resulted in the identification of many drug candidates are highlighted.