Journal ArticleDOI
Steroid 5 alpha-reductase: two genes/two enzymes.
David W. Russell,Jean D. Wilson +1 more
TLDR
The structure of the determinants of apoptosis, a type of cell death, and the role that individual cells play in this process are studied.Abstract:
BIOCHEMICAL PROPERTIES OF STEROID Sa-REDUCTASE . . . . . . . . . . . . 30 Protein Structure . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . 30 pH Optima . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Kinetic Constants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Overexpression and Purification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Intracellular Turnover and Subcellular Localization . . . . . . . . . . . . . . . . . . 36read more
Citations
More filters
Journal ArticleDOI
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
TL;DR: The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals and causes a spectrum of human disease; this ranges from liver failure in early childhood to progressive neuropathy in adults.
Journal ArticleDOI
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
TL;DR: Understanding steroidogenesis is of fundamental importance to understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiological homeostasis.
Journal ArticleDOI
A Putative Leucine-Rich Repeat Receptor Kinase Involved in Brassinosteroid Signal Transduction
Jianming Li,Joanne Chory +1 more
TL;DR: The identification of 18 Arabidopsis dwarf mutants that are unable to respond to exogenously added brassinosteroid, a phenotype that might be expected for brass inosteroid signaling mutants.
Journal ArticleDOI
Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
Anita H. Payne,Dale B. Hales +1 more
TL;DR: This review presents a detailed description of the enzymes involved in the biosynthesis of active steroid hormones, with emphasis on the human and mouse enzymes and their expression in gonads, adrenal glands, and placenta.
Journal ArticleDOI
The decline of androgen levels in elderly men and its clinical and therapeutic implications.
Jean Kaufman,Alex Vermeulen +1 more
TL;DR: Until the long-term risk-benefit ratio for androgen administration to elderly is established in adequately powered trials of longer duration, androgen administrations to elderly men should be reserved for the minority of elderly men who have both clear clinical symptoms of hypogonadism and frankly low serum testosterone levels.
References
More filters
Journal ArticleDOI
Studies on the possible existence of two 5α-reductases in the rat prostate
TL;DR: It is concluded that in the ventral prostate of the rat there are two different 5α-reductase isoenzymes, one sensitive to age and to the inhibitory effect of 4-OH-A (and which is responsible for the conversion of testosterone into the 5 α-reduced metabolites of the 17-OH series, DHT and the diols), and a second one, insensitive to age