Journal ArticleDOI
Studies in claisen rearrangement : Novel thermal transformation of α-aryloxymethylacrylic acids and their derivatives
TLDR
In this paper, the structure of α-Aryloxymethylacrylic acids and their derivatives has been revised on the basis of degradation studies, extensive spectral data and isolation of intermediates.About:
This article is published in Tetrahedron.The article was published on 1985-01-01. It has received 9 citations till now. The article focuses on the topics: Claisen rearrangement & Ene reaction.read more
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Reference EntryDOI
The Catalyzed α‐Hydroxyalkylation and α‐Aminoalkylation of Activated Olefins (The Morita—Baylis—Hillman Reaction)
TL;DR: The Baylis-Hillman reaction was first reported by Morita and Hillman as discussed by the authors, who reported the reaction of acetaldehyde with ethyl acrylate and acrylonitrile in the presence of catalytic amounts of 1,4-diazabicyclo[2.2] octane to give the α-hydroxyethylated products in good yields.
Patent
Compositions of protein receptor tyrosine kinase inhibitors
Jay Jie-Quiang Wu,Wang Ling +1 more
TL;DR: The use of substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA, is discussed in this paper.
Journal ArticleDOI
Dibromomethane as one-carbon source in organic synthesis: a versatile methodology to prepare the cyclic and acyclic α-methylene or α-keto acid derivatives from the corresponding terminal alkenes
TL;DR: Ozonolysis of mono-substituted alkenes A-1 followed by reacting with a preheated mixture of CH2Br2-Et2NH affords α-substantituted acroleins A-2 in good yields.
Journal ArticleDOI
Synergy or Competition between Palladium-Catalysis and KF/Alumina-Mediation for the Allylic Substitution of the Acetates of Baylis–Hillman Adducts by Phenols
TL;DR: In this paper, the addition of various substituted phenols to allylic acetates obtained from Baylis-Hillman adducts has been studied in the presence of a Pd(0) catalyst and/or KF/alumina.
Journal ArticleDOI
Access to racemic and enantioenriched 3-methyl-4-chromanones: catalysed asymmetric protonation of corresponding enolic species as the key step
TL;DR: Bronsted acids induced the intramolecular cyclisation of 3-aryloxypropanoic esters affording 3-methyl-4-chromanones, which have been transformed into the corresponding racemic benzyl β-oxoesters.
Related Papers (5)
Synthesis and claisen rearrangement of 1-allyloxy-1-carbomethoxy allenes
M.J. Sleeman,G.V. Meehan +1 more