Journal ArticleDOI
Studies on Cephalosporin-C production using immobilised cells of Cephalosporium acremonium in a packed bed reactor
TLDR
A cells-to-carrier ratio of 3:2 was found to be optimum throughout these studies and the effect of recycle ratio indicated diffusion barriers to substrate transport.About:
This article is published in Process Biochemistry.The article was published on 1992-11-01. It has received 14 citations till now. The article focuses on the topics: Calcium alginate & Cephalosporin C.read more
Citations
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Journal ArticleDOI
Studies on cephalosporin-C production in an air lift reactor using different growth modes of Cephalosporium acremonium
Pradeep Srivastava,Subir Kundu +1 more
TL;DR: Cephalosporin-C production was significantly improved by using bioparticles over the free mycelial culture, probably due to the enhanced mass transfer in the fermentation broth, but the biofilm of the bioparticle became unstable as the fermentation proceeded, and increase in the free cells in the broth occurs.
Journal ArticleDOI
Production of cephalosporin C by immobilized Cephalosporium acremonium in polyethyleneimine-modified barium alginate
Hong-Je Park,Yong-Ho Khang +1 more
TL;DR: Calcium, barium, and strontium alginates were studied to develop a suitable gel matrix for the immobilization of Cephalosporin C (CPC) and yielded better results in both gel stability and cell activity than Ca- and Sr-alginates.
Journal ArticleDOI
A comparative evaluation of Cephalosporin C production using various immobilization modes.
Pradeep Srivastava,Subir Kundu +1 more
TL;DR: The production of Cephalosporin C was investigated in a lab-scale 1.4 l air-lift reactor (ALR), using various immobilization modes that exhibited enhanced volumetric oxygen transfer coefficient and well-controlled, three-phase hydrodynamics.
Journal ArticleDOI
Improved production of Daptomycin in an airlift bioreactor by morphologically modified and immobilized cells of Streptomyces roseosporus
Ipsita Chakravarty,Subir Kundu +1 more
TL;DR: Cell immobilization improved the three phase broth rheology and hence, the hydrodynamics within the reactor and therefore, whole-cell immobilization could contribute to the ameliorated production of this life-saving drug.
Journal ArticleDOI
Continuous production of cephalosporin-C by immobilized microbial cells using symbiotic mode in a packed bed bioreactor.
TL;DR: The whole cell immobilization technique is a potentially important process for Cephalosporin‐C biosynthesis, where increase cell densities were maintained and broth‐handling problems were reduced and operational stability of immobilized systems in a packed bed reactor was studied.
References
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Journal ArticleDOI
Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar
Journal ArticleDOI
The Effect of Lipids on Citric Acid Production by an Aspergillus niger Mutant
TL;DR: A mutant strain, 72--44, of Aspergillus niger was selected after ultraviolet irradiation of the spores of A. niger strain 72--4, capable of giving high yields of citric acid in shaken flask fermentations.
Journal ArticleDOI
Effect of carbon sources on β-lactam antibiotic formation by Cephalosporium acremonium
Yves M. Kennel,Arnold L. Demain +1 more
TL;DR: Fermentations conducted with different concentrations of glucose showed that β -lactam formation was markedly accelerated only when glucose was exhausted, which support the concept of carbon source control of antibiotic synthesis in C. acremonium.
Journal ArticleDOI
Enhanced β-lactam antibiotic production by coimmobilization of fungus and alga
TL;DR: It was determined that Cephalosporium acremonium, an oxygenconsuming fungus, had a symbiotic relationship with Chlorella pyrenoidosa, a oxygen-generating alga, and the fungus and the alga were coimmobilized by entrapment in calcium alginate beads.
Related Papers (5)
A comparative evaluation of Cephalosporin C production using various immobilization modes.
Pradeep Srivastava,Subir Kundu +1 more