Journal ArticleDOI
Studies on cytokines related to wound healing in donor site wound fluid
TLDR
It is increased the likelihood that film or hydrocolloid dressings will be used more frequently in the future for treatment of burn wounds, ulcers or donor-site wounds since these dressings were shown to be more capable of retaining cytokines, particularly intrinsic growth factors secreted at the wound site.Citations
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Regulation of Wound Healing by Growth Factors and Cytokines
Sabine Werner,Richard Grose +1 more
TL;DR: This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds and reports on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
Journal ArticleDOI
Keratinocyte–Fibroblast Interactions in Wound Healing
TL;DR: This review focuses on the role of keratinocyte-fibroblast interactions in the wound-healing process and the phenotype of fibroblasts from different tissues or body sites becomes better defined, so as to understand their individual contribution in wound healing in more detail and possibly explain different clinical outcomes.
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Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts
Won Serk Kim,Byung Soon Park,Jong Hyuk Sung,Jun-Mo Yang,Seok Beom Park,Sahng June Kwak,Jeong-Soo Park +6 more
TL;DR: Data suggest that ADSC is constitutionally well suited for dermal wound healing and secretory factors derived from ADSCs promote wound healing via HDFs and ADSCs can be used for the treatment of photoaging and wound healing.
Journal ArticleDOI
Wound re-epithelialization: modulating keratinocyte migration in wound healing.
TL;DR: This review focuses on the mechanisms that regulate keratinocyte migration in the re-epithelialization process and the role of growth factors, cytokines and chemokines, eicosanoids, oxygen tension, antimicrobial peptides, and matrix metalloproteinases.
Journal ArticleDOI
Self-Assembling Peptide Nanofiber Scaffolds Accelerate Wound Healing
TL;DR: The experiments demonstrated that biomaterials composed of a biofunctionalized peptidic scaffold have many properties that are well-suited for the treatment of cutaneous wounds including wound coverage, functionalization with bioactive molecules, localized growth factor release and activation of wound repair.
References
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Journal ArticleDOI
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.
Thomas A. Mustoe,Glenn F. Pierce,Arlen R. Thomason,Peggy Gramates,Michael B. Sporn,Thomas F. Deuel +5 more
TL;DR: TGF-beta is a potent pharmacologic agent that can accelerate wound healing in rats and is accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF- beta.
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Enhancement of wound healing by topical treatment with epidermal growth factor.
Gregory L. Brown,Lillian B. Nanney,Joseph Griffen,Anne B. Cramer,John M. Yancey,Luke J. Curtsinger,Larry Holtzin,Gregory S. Schultz,Maurice J. Jurkiewicz,John B. Lynch +9 more
TL;DR: It is concluded that epidermal growth factor accelerates the rate of healing of partial-thickness skin wounds and further studies are required to determine the clinical importance of this finding.
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Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.
Glenn F. Pierce,Thomas A. Mustoe,J Lingelbach,V R Masakowski,Gail L. Griffin,Robert M. Senior,Thomas F. Deuel +6 more
TL;DR: In contrast, PDGF is a more potent chemoattractant for wound macrophages and fibroblasts and may stimulate these cells to express endogenous growth factors, including TGF-beta, which may stimulate new collagen synthesis and sustained enhancement of wound healing over a more prolonged period of time.
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Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor
Gregory S. Schultz,Michael J. White,Robert A. Mitchell,Gregory L. Brown,Jenny Lynch,Daniel R. Twardzik,George J. Todaro +6 more
TL;DR: This paper showed that topical administration of TGF-alpha or VGF in antibiotic cream to partial thickness burns (second degree) accelerated epidermal regeneration in comparison with untreated or vehicle-treated burns.
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Enhancement of epidermal regeneration by biosynthetic epidermal growth factor.
Gregory L. Brown,Luke J. Curtsinger,Joseph Brightwell,Douglas Ackerman,Gordon R. Tobin,Hiram C. Polk,Carlos George-Nascimento,Pablo Valenzuela,Gregory S. Schultz +8 more
TL;DR: The results of this study show that topical application of biosynthetic human epidermal growth factor acceleratesEpidermal regeneration in split-thickness wounds and partial-thickenness burns, suggesting the potential for clinical use of epider mal growth factor for accelerating healing of burns, wounds from trauma, diabetic ulcers, skin graft donor sites, and others.