Journal ArticleDOI
Studies on the inhibition of hepatic lipogenesis by N6,O2′-dibutyryl adenosine 3′,5′-monophosphate☆
TLDR
The profile of metabolic intermediates suggests that N6,O2′-dibutyryl adenosine 3′,5′-monophosphate inhibits the conversion of glycogen to pyruvate and lactate by decreasing the effectiveness of phosphofructokinase and pyruVate kinase.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1975-07-01. It has received 173 citations till now. The article focuses on the topics: Pyruvate decarboxylation & Pyruvate dehydrogenase kinase.read more
Citations
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Journal ArticleDOI
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
Douglas Osei-Hyiaman,Michael Depetrillo,Pal Pacher,Jie Liu,Svetlana Radaeva,Sandor Batkai,Judith Harvey-White,Ken Mackie,László Offertáler,Lei Wang,George Kunos +10 more
TL;DR: It is concluded that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation.
Journal ArticleDOI
Fructose 2,6-bisphosphate 2 Years After its Discovery
TL;DR: Fru-2,6-P2 is not an intermediary metabolite of glycolysis, but its most potent regulator and its potential role in the control of metabolism in various organisms is delineated.
Journal ArticleDOI
Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase.
TL;DR: Findings open new perspectives for the simultaneous control of triglyceride and cholesterol synthesis by pharmacological stimulators of AMP‐activated protein kinase.
Journal ArticleDOI
The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.
TL;DR: The present studies support the concept that malonyl-CoA plays a pivotal role in the coordination of hepatic fatty acid synthesis and oxidation, and the ketogenic effect of glucagon on liver appears to be manifested in large part through the ability of the hormone to reduce the tissue maloneyl- CoA concentration.
Journal ArticleDOI
In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis.
J. D. McGarry,Daniel W. Foster +1 more
TL;DR: It is established that the changes in fatty acid oxidation and ketogenesis produced by fasting can be entirely accounted for by removal of the malonyl-CoA-mediated inhibition of carnitine acyltransferase I activity, coupled with a rise in hepatic carnitines content.
References
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Journal ArticleDOI
HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study
M. N. Berry,Daniel S. Friend +1 more
TL;DR: Cytoplasmic vacuolization in a small percentage of cells and potassium loss are the only indications of cell injury detected, and the isolated cells are comparable to normal hepatic parenchymal cells in situ in appearance and function.
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Removal of Fatty Acids from Serum Albumin by Charcoal Treatment
TL;DR: Fluorescence spectra of human serum albumin samples indicated that impurities are sometimes present which can be removed by charcoal at neutral pH, and acid-charcoal treatment is a much more rapid method of removing lipid impurities than other methods previously described.
Journal ArticleDOI
The Redox State of Free Nicotinamide-Adenine Dinucleotide in the Cytoplasm and Mitochondria of Rat Liver
TL;DR: The bearing of these findings on various problems, including the number of NAD(+)-NADH pools in liver cells; the applicability of the method to tissues other than liver; the transhydrogenase activity of glutamate dehydrogenase; the physiological significance of the difference of the redox states of mitochondria and cytoplasm; aspects of the regulation of theredox state of cell compartments; the steady-state concentration of mitochondrial oxaloacetate.
Journal ArticleDOI
Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in blood
Journal ArticleDOI
The redox state of free nicotinamide–adenine dinucleotide phosphate in the cytoplasm of rat liver
TL;DR: The application of the method of calculation to data published by Kraupp, Adler-Kastner, Niessner & Plank (1967), Goldberg, Passonneau & Lowry (1966) and Kauffman, Brown,passonneau and Lowry (1968) shows that the redox states of the NAD and NADP couples in cardiac-muscle cytoplasm and in mouse-brain cytop lasm are of the same order as those in rat liver.
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HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study
M. N. Berry,Daniel S. Friend +1 more