Studies on the mechanism of swelling, lysis, and distintegration of isolated liver mitochondria exposed to mixtures of oxidized and reduced glutathione.
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TLDR
Investigations are reported on GSHand GSSG + GSH-induced swelling, the mechanism of action of glutathione on mitochondrial membranes is of special interest because of evidence suggesting that disulfide interchange reactions in membrane structures may control permeability.About:
This article is published in Journal of Biological Chemistry.The article was published on 1964-02-01 and is currently open access. It has received 128 citations till now. The article focuses on the topics: Glutathione & Lysis.read more
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Selective modification of glutathione metabolism
TL;DR: Modifications of glutathione metabolism may be achieved by administration of selective enzyme inhibitors, and also by giving compounds that increase glutATHione synthesis, which are useful in chemotherapy and radiation therapy and in protecting cells against the toxic effects of drugs, other foreign compounds, and oxygen.
Journal ArticleDOI
Carbon tetrachloride hepatotoxicity: an example of lethal cleavage
Rechnagel Ro,Glende Ea +1 more
TL;DR: In this paper, an example of Lethal Cleavage is presented. But it is based on Carbon Tetrachloride Hepatotoxicity (CTH) and it does not consider the effect of carbon dioxide.
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Free radicals in cerebral ischemia.
TL;DR: The possibility that cerebral ischemia may initiate a series of pathological free radical reactions within the membrane components of the CNS was investigated in the cat and there was a progressive decrease in the amount of detectable ascorbic acid following middle cerebral artery occlusion.
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Lipid peroxide formation in microsomes. General considerations
TL;DR: It is considered that lipid peroxide formation occurs as a result of the operation of the microsomal electron-transport chain switching from hydroxylation to oxidize unsaturated lipids of the endoplasmic reticulum.
References
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Water uptake and extrusion by mitochondria in relation to oxidative phosphorylation.
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Swelling and lysis of rat liver mitochondria induced by ferrous ions.
TL;DR: These studies with isolated mitochondria provide additional information about structure and permeability control in the mitochondrial membranes as well as investigating the action of added iron.
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Lipide peroxidation in isolated mitochondria
Al L. Tappel,H. Zalkin +1 more
TL;DR: Isolated mitochondria suspended in 0.15 M NaCl at 37 °C deteriorate by a hematin-catalyzed lipide peroxidation, characterized by oxygen absorption, thiobarbituric acid reaction, and enzyme inactivation.
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The effect of thiols and disulfides on water uptake and extrusion by rat liver mitochondria.
TL;DR: A more detailed study of the action of various thiols and disulfides on both water uptake and extrusion in rat liver mitochondria is described to develop a more reproducible and specific assay system for the purification of C-factor and to assist in interpreting the chemical nature of theaction of glutathione and C-Factor on mitochondrial structure.