Journal ArticleDOI
Surface tension of amino acid solutions: A hydrophobicity scale of the amino acid residues
Henry B. Bull,Keith Breese +1 more
Reads0
Chats0
TLDR
From the experimental results, the free energies of transfer of the amino acid residues from the solution to the surface have been calculated to yield a hydrophobicity scale of the residues, in fairly good agreement with that of Nozaki and Tanford.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1974-04-01. It has received 449 citations till now. The article focuses on the topics: Hydrophobicity scales & Amino acid.read more
Citations
More filters
Journal ArticleDOI
A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more
TL;DR: A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised and its simplicity and its graphic nature make it a very useful tool for the evaluation of protein structures.
Journal ArticleDOI
New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites.
TL;DR: It was found that the HPLC parameters obtained in this study correlated best with antigenicity, and it was shown that a combination of the three best parameters for predicting antigenicity further improved the predictions.
Journal ArticleDOI
Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence
Roy D. Sleator,Colin Hill +1 more
TL;DR: The molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, are reviewed, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment.
Journal ArticleDOI
Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins
James L. Cornette,Kemp B. Cease,Hanah Margalit,John L. Spouge,Jay A. Berzofsky,Charles DeLisi +5 more
TL;DR: Although the scale is optimal only for predicting alpha-amphipathicity, it also ranks high in identifying beta-ampshipathicity and in distinguishing interior from exterior residues in a protein.
References
More filters
Book ChapterDOI
Some factors in the interpretation of protein denaturation.
TL;DR: The chapter reviews that the denaturation is a process in which the spatial arrangement of the polypeptide chains within the molecule is changed from that typical of the native protein to a more disordered arrangement.
Journal ArticleDOI
The Solubility of Amino Acids and Two Glycine Peptides in Aqueous Ethanol and Dioxane Solutions ESTABLISHMENT OF A HYDROPHOBICITY SCALE
Yasuhiko Nozaki,Charles Tanford +1 more
TL;DR: In this article, the free energies of transfer of amino acid side chains and backbone peptide units from water to ethanol and dioxane solutions have been calculated from these data and the results show the similarity between the effects of ethanol and Dioxane on the stability of those side chains.
Related Papers (5)
A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more
The Solubility of Amino Acids and Two Glycine Peptides in Aqueous Ethanol and Dioxane Solutions ESTABLISHMENT OF A HYDROPHOBICITY SCALE
Yasuhiko Nozaki,Charles Tanford +1 more