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Synthesis and antimicrobial properties of S-substituted derivatives of 2-thiouracil.
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The synthesis of 24 new 2-alkylthio and 2-(E)-N-thioalkyl-4-azachalkonyl substituted derivatives of uracil showed a good antibacterial activity against Staphylococcus aureus and Streptococcus faecalis.Abstract:
The synthesis of 24 new 2-alkylthio and 2-(E)-N-thioalkyl-4-azachalkonyl substituted derivatives of uracil and their antimicrobial activity are reported. In particularly compounds 6o and 6p showed a good antibacterial activity against Staphylococcus aureus and Streptococcus faecalis.read more
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Synthesis of certain pyrimidine derivatives as antimicrobial agents and anti-inflammatory agents.
TL;DR: A variety of novel bicyclic and tricyclic pyrimidine derivatives was obtained via reaction of 6-amino-2-thioxo-1H-pyrimidine-4-one with a different reagents.
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Design, synthesis of new pyrimidine derivatives as anticancer and antimicrobial agents
TL;DR: All of the new synthesized compounds were tested in vitro for their antiproliferative activities against HePG-2 and MCF-7 cell lines and displayed potent growth inhibitory effect toward the two cell lines more than the standard drug 5-FU.
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Experimental study on the thermochemistry of 2-thiouracil, 5-methyl-2-thiouracil and 6-methyl-2-thiouracil
TL;DR: In this paper, the Clausius-Clapeyron equation was used to derive the standard molar enthalpies of formation of the investigated compounds in their condensed and gaseous phases, respectively.
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Synthesis and antimicrobial properties of N-substituted derivatives of (E)-4-azachalcones.
TL;DR: Compounds 3d, 3e, 6b, 6c, and 6e reveal good antimicrobial activity against Staphylococcus aureus and Enterococcus faecalis as well as moderate activity against Escherichia coli and Klebsiella pneumoniae.
Journal ArticleDOI
An Efficient, Clean, and Catalyst-Free Synthesis of Fused Pyrimidines Using Sonochemistry
TL;DR: In this paper, the synthesis of indenopyrido[2,3-d]pyrimidine and pyrimido[4,5-b]quinoline derivatives was investigated via one-pot three-component reaction between 6-amino-2-(alkylthio)-pyrimidin-4(3H)one, 1,3indanedione, or 1-3-cyclohexadione and arylaldehyde under ultrasonic irradiation in ethylene glycol as solvent at 65°C.