Journal ArticleDOI
Synthesis and Fungicidal Activity of Some New 4H-Chromen-4-ones Containing Some 1,3-Thiazole, 1,3-Thiazine, 1,2,4-Triazole and 1,2,4-Triazine Moieties
TLDR
In this paper, the potassium salt of carbamodithioic acid derivative 3 reacted with some electrophiles reagents to afford the 2-thioxo-1,3-thiazoles 4-5 and 2.5-6 derivatives.Abstract:
The potassium salt of carbamodithioic acid derivative 3 reacted with some electrophiles reagents to afford the 2-thioxo-1,3-thiazoles 4–5 and 2-thioxo-1,3-thiazines 6–7 derivatives. Heterocyclization of compound 3 with amino-mercapto compounds 8–9 and/or hydrazine derivatives 12–13 yielded 3-thioxo-1,2,4-triazoles 10–11 and 3-thioxo-1,2,4-triazines 14–15 , respectively. Structures of the products have been determined by elemental and spectral methods. All the new compounds have been screened for their fungicidal activity.read more
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Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents.
TL;DR: In this article, the authors showed that 5,6-diphenyl-3-hydrazino-1,2,4-triazine (1) with bis(methylthio)methylene]malononitrile (2) with benzoyl chloride and sodium pyruvate (3) with acetic anhydride produced pyrazolo[5,4,3-kl]pyrimido[4, 3-d]pyridine 6, which was allowed to react with hydrazine hydrate to give the corresponding hyd
Journal ArticleDOI
Synthesis and antibacterial activity of some new thiadiaza/triazaphospholes, thiadiaza/triaza/tetrazaphosphinines and thiadiaza/tetrazaphosphepines containing 1,2,4-triazinone moiety.
TL;DR: In vitro antibacterial activities of the synthesized compounds exhibited good inhibitory activities against most the tested organisms with MIC values in the range 6.25-12.5 microg/mL and lower cytotoxicity in comparison with the reference drugs.
Journal ArticleDOI
Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties
TL;DR: Some new sulfur-nitrogen heterocyclic systems such as 1, 3-thiazoles, 1,3,4-thiadiazoles and 1, 2, 4-triazoles incorporating acridine and 1 2, 3, 4 -tetrahydroacridine moieties were synthesized via heterocycling of the key intermediate 4-(acridin-9-yl)-1-(1, 2.3, 4t, 4, 4)-thiosemicarbazide as discussed by the authors.
Journal ArticleDOI
Thiazolidinones: Synthesis, Reactivity, and Their Biological Applications
Journal ArticleDOI
Synthesis, characterization and antibacterial screening of some novel 1,2,4-triazine derivatives
TL;DR: A new series of 1, 2, 4-triazine derivatives possessing indole nucleus were synthesized with an aim to explore their effect on in vitro growth of microorganisms causing microbial infection and some compounds were found to exhibit better activity with less toxicity than Ciprofloxacin.
References
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Journal ArticleDOI
Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds.
TL;DR: Two novel series of 4-thiazolidinone derivatives, namely 2-substituted-3-([4-(4-methoxybenzoylamino)benZoyl]amino)-4-thiaircraftino-1,3,4-oxadiazoles and 7a-e, have been synthesised as title compounds and showed significant antimicrobial activity against the microorganisms used.
Journal ArticleDOI
Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones.
TL;DR: The 5-arylidene derivatives showed an antibacterial efficacy considerably greater than that of the parent 2-(thiazol-2-ylimino)thiazolidin-4-one 3, suggesting that the substituted and unsubstituted 5- Darylidene moiety plays an important role in enhancing the antimicrobial properties of this class of compounds.
Journal ArticleDOI
Studies on antianaphylactic agents—III
TL;DR: By the application of the Vilsmeier-Haack reaction to various o-hydroxyacetophenone derivatives, 4-oxo-4H-1-benzopyran-3-carboxaldehydes were synthesized in one step as discussed by the authors.
Journal ArticleDOI
Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Flavonoid Derivatives and Analogues
Mohamed Hadjeri,Magali Barbier,Xavier Ronot,Anne-Marie Mariotte,Ahcène Boumendjel,Jean Boutonnat +5 more
TL;DR: 5-hydroxy-2-(4-methylpiperazin-1-ylcarbonyl)chromone (4a) was found to be a powerful reversal agent, more potent than cyclosporin A, used as the reference molecule, and no effect was observed on MRP transport nor on cell proliferation.
Journal ArticleDOI
Synthesis and structure elucidation of some new thioether derivatives of 1,2,4-triazoline-3-thiones and their antimicrobial activities
TL;DR: The antibacterial, antifungal and antimycobacterial activities, together with those of known intermediate 1,4-disubstituted thiosemicarbazides, were reported.