Journal ArticleDOI
Synthesis and In Vitro Anticancer Evaluation of Some Benzimidazolium Salts
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This article is published in Journal of Heterocyclic Chemistry.The article was published on 2019-10-01. It has received 21 citations till now.read more
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Anticancer activities of various new metal complexes prepared from a Schiff base on A549 cell line
TL;DR: In this article, a new compound namely 1-((2-hydroxynaphthalen-1-yl)methyleneamino)-5-(4-methybenzoyl)-4-p-tolylpyrimidin-2(1H)-one (S2) was synthesized as a Schiff base using 1-amino-5-( 4-methyl benzoyal)-4-(4methylphenyl)pyrimidIN-2 (1H-one) with 2-hydroxy-1 naphthaldehyde in 80
Journal ArticleDOI
Investigation of structural, spectral, electronic, and biological properties of 1,3-disubstituted benzimidazole derivatives
TL;DR: In this article, the X-ray diffraction technique was applied to study the structure of (C23H19N4O2)+.Br−.H2O, namely 1-[(2-cyanophenyl)methyl]-3-[2-(4-nitrophenyl)ethyl]-1H-benzimidazol-3-ium bromide monohydrate (S3).
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Synthesis, cytotoxic activity and quantum chemical calculations of new 7-thioxopyrazolo[1,5-f]pyrimidin-2-one derivatives
Zülbiye Kökbudak,Murat Saracoglu,Senem Akkoç,Zeynep Çimen,M. Izzettin Yilmazer,Fatma Kandemirli +5 more
TL;DR: In this paper, the reaction of 1-amino-2-thioxo-1,2-dihydropyrimidin derivatives 1 and 2 with chloroacetyl chloride in the presence of sodium acetate led to the formation of 7thioxopyrazolo [1,5-f]pyrimidIN-2(1H,3H,7H)-one derivatives (3 and 4) in 78-80% yields.
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The cytotoxic activities of imidazole derivatives prepared from various guanylhydrazone and phenylglyoxal monohydrate
TL;DR: Almost all the compounds synthesized from two-component condensation reaction of phenylgloxal monohydrate with guanylhydrazone gave more cytotoxic results than cisplatin, and could be considered for further development as anticancer drug candidates.
References
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Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents.
TL;DR: In the present review, published reports on benzimidazole scaffold are collated to provide an insight so that its full therapeutic potential can be utilized for the treatment of pain and inflammation.
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Benzimidazole condensed ring system. IX. Potential antineoplastics. New synthesis of some pyrido[1,2-α]benzimidazoles and related derivative
TL;DR: Pyrido[1,2-a]benzimidazoles exhibited a good in vitro antineoplastic activity with subpanel disease selectivity, particularly against most of the cell lines of leukemia and some cell lines from colon, melanoma and renal cancer panels.
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Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts.
TL;DR: This review will focus on recent advances of Ag(I)-NHCs in medicinal applications demonstrating comparable or better antitumor activity than standard chemotherapeutics such as cisplatin and 5-fluorouracil.
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Silver(I) complexes of mono- and bidentate N-heterocyclic carbene ligands: synthesis, crystal structures, and in vitro antibacterial and anticancer studies.
TL;DR: Preliminary in vitro antibacterial potentials of reported compounds against a Gram negative (Escherichia coli) and a Gram positive (Bacillus subtilis) bacteria evidenced the higher activity of mononuclear silver(I) complexes.
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N-heterocyclic carbenes (NHC) with 1,2,4-oxadiazole-substituents related to natural products: synthesis, structure and potential antitumor activity of some corresponding gold(I) and silver(I) complexes.
Catalin V. Maftei,Elena Fodor,Peter G. Jones,Matthias Freytag,M. Heiko Franz,Gerhard Kelter,Heinz-Herbert Fiebig,Matthias Tamm,Ion Neda +8 more
TL;DR: This work presents the synthesis, characterization and application of eleven new gold (I) complexes 13-23 with 1,2,4-oxadiazole-containing N-heterocyclic carbene (NHC) ligands and of the NHC silver(I) complex 24.