Open AccessJournal Article
Synthesis and potential antimicrobial activity of some new compounds containing the pyrazol-3-one moiety
TLDR
In this article, the nucleophilic addition of 2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one (1) to chalcone (2) was described.Abstract:
Pyrazolone derivative 3 was prepared by the nucleophilic addition of 2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one (1) to chalcone (2). Reaction of 3 with hydrazine hydrate, phenylhydrazine, hydroxylamine hydrochloride, p-chlorobenzaldehyde, acetyl chloride and phosphorus pentasulfide afforded the corresponding hydrazone, phenylhydrazone, oxime, arylidene, O-acetyl and dithio derivatives. Pyrazolone 1 was condensed also with cyclohexanone and aromatic aldehydes; the behaviour of the obtained arylidene derivatives towards hydrazines, cyclohexanone, malononitrile and urea was also investigated. Some of the new compounds showed antimicrobial and antifungal activities.read more
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Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation
TL;DR: alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thIO acetic acid ethyl esters with acid chlorides and screened for their antibacterial, antifungal activities.
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A novel pyrazolone, 4,4-dichloro-1-(2,4-dichlorophenyl)-3-methyl-5-pyrazolone, as a potent catalytic inhibitor of human telomerase.
Yasutaka Kakiuchi,Narie Sasaki,Mieko Satoh-Masuoka,Hiromu Murofushi,Kimiko Murakami-Murofushi +4 more
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Synthesis of some new annulated pyrazolo-pyrido (or pyrano) pyrimidine, pyrazolopyridine and pyranopyrazole derivatives.
TL;DR: The bifunctional pyrazolopyridine and pyrano-pyrazole derivatives were prepared by the reaction of p-methoxybenzaldehyde, malononitrile in the presence of ammonium acetate or piperidine, respectively.
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A facile four-component sequential protocol in the expedient synthesis of novel 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones in water and their antitubercular evaluation.
TL;DR: A series of 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones has been synthesized by one-pot, four-component sequential reactions of phenylhydrazine, methyl acetoacetate, aromatic aldehydes and β-naphthol in the presence of p-toluenesulphonic acid in water in good yields.
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Sonochemically synthesis of pyrazolones using reusable catalyst CuI nanoparticles that was prepared by sonication
TL;DR: This nanoparticles was used as an efficient catalyst for the synthesis of 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones via four-component reaction of hydrazine, ethyl acetoacetate, aldehyde and β-naphthol in water under ultrasound irradiation.