Journal ArticleDOI
Synthesis and turnover of DNA-bound histone during maturation of avian red blood cells.
R. Appels,Julian R.E. Wells +1 more
TLDR
The metabolism of f2c histone in non-dividing avian red blood cells may be an example of a more general phenomenon for other histones (particularly f 1 histones) in other tissues, and that the important feature which relates histones to the over-all potential of chromatin for transcription is not the static level of histone but rather the dynamic state of its synthesis and its release from DNA.About:
This article is published in Journal of Molecular Biology.The article was published on 1972-10-14. It has received 81 citations till now. The article focuses on the topics: Histone H2A & Histone methyltransferase.read more
Citations
More filters
Journal ArticleDOI
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding
TL;DR: The structure of GH5, the globular domain of the linker histone H5, has been solved to 2.5 Å resolution by multiwavelength anomalous diffraction on crystals of the selenomethionyl protein, thereby providing a possible model for the binding ofGH5 to DNA.
Journal ArticleDOI
Processing of newly synthesized histone molecules
TL;DR: The structural function of histones is to organize the long, fibrillar molecules of DNA into a more compact form, achieved, in part, by electrostatic interactions between the positively charged basic amino acids in the histone polypeptide chains and the negatively charged phosphate groups of DNA.
Journal ArticleDOI
Chromatin structure of transcriptionally competent and repressed genes.
TL;DR: Transcriptionally competent erythrocyte chromatin fragments, in contrast to inactive fragments, are unable to self‐associate into ‘pseudo‐higher‐order structures’, a consequence of the partial depletion of H5 and/or H1 in active chromatin.
Journal ArticleDOI
Histone H10 accumulates in growth-inhibited cultured cells.
John Pehrson,R. David Cole +1 more
TL;DR: It is demonstrated that H10 accumulated along with the arrest of cell division in a single cell type, a demonstration using cultured cells that is consistent with the notion that histone H10 suppresses gene replication.
Journal ArticleDOI
Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. A biological process mediated through the insulin receptor.
F C Kosmakos,J Roth +1 more
TL;DR: Reduction in the temperature of the preincubation from 37 degrees C to 20 degrees C (which enhanced the total amount of insulin bound to the receptor) abolished the loss of insulin receptors, and cycloheximide prevented the insulin-induced loss of receptors.
References
More filters
Journal ArticleDOI
The heterogeneity of histones. I. A quantitative analysis of calf histones in very long polyacrylamide gels.
Sakol Panyim,Roger Chalkley +1 more
Journal ArticleDOI
The stepwise removal of histones from chicken erythrocyte nucleoprotein.
K. Murray,G. Vidali,J. M. Neelin +2 more
TL;DR: The histone fraction that is apparently unique to avian erythrocytes was obtained without contamination by other histone fractions, and the chromatographic behaviour and amino acid composition of the components permitted comparison with histones prepared by other methods.
Journal ArticleDOI
Dna synthesis in purified populations of avian erythroid cells
TL;DR: Cells from both the unfractionated and purified preparations have been characterized in terms of their histological type, size, haemoglobin content and ability to synthesize DNA.
Journal ArticleDOI
Sites of in vivo acetylation in trout testis histone IV.
E. P. M. Candido,Gordon H. Dixon +1 more
TL;DR: Four lysyl residues in the NH2-terminal region at positions 5, 8, 12, and 16 were found to be acetylated in a fraction of the histone IV molecules, which leads to a complex mixture of modified histone III molecules, partially reflected in the starch gel pattern of this protein.
Journal ArticleDOI
Heterogeneity and Polymorphism in Chicken Erythrocyte Histone Fraction V
P. J. Greenaway,Kenneth Murray +1 more
TL;DR: Histone fraction V, which occurs uniquely in nucleated erythrocytes, is polymorphic and examples involving glutamine and arginine at amino-acid No. 15 have been found in individual chickens.