Journal ArticleDOI
Synthesis, Cytotoxic and Phytotoxic Effects of Some New N4-Aryl Substituted Isatin-3-thiosemicarbazones
Reads0
Chats0
About:
This article is published in Letters in Drug Design & Discovery.The article was published on 2011-05-31. It has received 19 citations till now. The article focuses on the topics: Isatin & Aryl.read more
Citations
More filters
Journal ArticleDOI
QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent
TL;DR: Quant mechanical (QM) method including functional B3LYP in association with split valence basis set using polarization functions (Def2-SVP) was used to estimate individual ligand-residue interaction energies for the docked 3-(2-(4-nitrophenyl)hydrazono) indolin-2-one into VEGFR-2 active site.
Journal ArticleDOI
Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents.
Kailin Han,Yao Zhou,Fengxi Liu,Qiannan Guo,Pengfei Wang,Yao Yang,Song Binbin,Wei Liu,Qingwei Yao,Yuou Teng,Peng Yu +10 more
TL;DR: This study leads to the identification of two highly active molecules, compounds 2h (IC50=3 nM) and 2k (IC 50=6 nM), against human leukemia K562 cells.
Journal ArticleDOI
Synthesis, biological activity and docking study of some new isatin Schiff base derivatives
TL;DR: Based on the ligand efficiency indices, some isoxazole or thiazole substituted isatin derivatives may be regarded as efficient candidates for further molecular developments of anticancer agents.
Journal ArticleDOI
Synthesis and anti-cancer activity evaluation of 5-(2-carboxyethenyl)-isatin derivatives.
Yuou Teng,Hong-Ye Zhao,Jing Wang,Huan Liu,Mei-Le Gao,Yao Zhou,Kailin Han,Zhen-Chuan Fan,Yong-Min Zhang,Hua Sun,Peng Yu +10 more
TL;DR: A series of novel di- or trisubstituted isatin derivatives were designed and synthesized in 5-6 steps in 25-45% overall yields and it was obvious that compound 2h inhibited the proliferation of Jurkat cells through the mitochondrial apoptotic pathway.
Book ChapterDOI
Recent highlights in the development of isatin- based anticancer agents
TL;DR: Recent highlights in the development of isatin-based compounds as anticancer agents are reviewed with a particular focus on the cytotoxicity and structure activity relationships.