Journal ArticleDOI
Synthesis of the smallest axially chiral molecule by asymmetric carbon-fluorine bond activation.
Moritz F. Kuehnel,Tobias Schlöder,Sebastian Riedel,Belén Nieto-Ortega,Francisco J. Ramírez,Juan T. López Navarrete,Juan Casado,Dieter Lentz +7 more
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The previously reported structures derived frommicrowave spectroscopy do not show the same distortions, because erroneously, therefinement was based on a constrained linear geometry.Abstract:
Surprisingly, thecarbon backbones of 3 and 5adeviate by 4.4(3)8 and 4.6(2)8from the linearity that would be expected based on their sp-hybridized central carbon atoms (Figure 2). Furthermore, thetwo terminal F-C-H planes in5a have a torsion angle of91.9(2)8. The previously reported structures derived frommicrowave spectroscopy do not show the same distortions(Supporting Information, Table S2), because erroneously, therefinement was based on a constrained linear geometry.read more
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Functionalization of fluorinated molecules by transition-metal-mediated C-F bond activation to access fluorinated building blocks.
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Synthesis of fluorinated building blocks by transition-metal-mediated hydrodefluorination reactions.
TL;DR: An overview of transition-metal-based complexes and catalysts that were developed to mediate hydrodefluorination reactions is provided and future requirements for further developing this field will be highlighted.
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Ketenes and Other Cumulenes as Reactive Intermediates
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Synthese fluorierter Bausteine durch Übergangsmetall‐vermittelte Hydrodefluorierungsreaktionen
TL;DR: In this article, aufsatz fasst Aspekte zur Hydrodefluorierung mithilfe Ubergangsmetall-basierter Komplexe und Katalysatoren zusammen and legt dabei besonderes Augenmerk auf die zugrundeliegenden mechanistischen Muster and deren Einfluss auf Anwendungsbreite and Selektivitat des jeweiligen Systems.
References
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Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
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Stratospheric sink for chlorofluoromethanes: chlorine atomc-atalysed destruction of ozone
Mario J. Molina,F. S. Rowland +1 more
TL;DR: Chlorofluoromethanes are being added to the environment in steadily increasing amounts as discussed by the authors and these compounds are chemically inert and may remain in the atmosphere for 40 to 150 years, and concentrations can be expected to reach 10 to 30 times present levels.
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Catalysis for fluorination and trifluoromethylation
TL;DR: Reactions to make organofluorides that have emerged within the past few years are discussed and which exemplify how to overcome some of the intricate challenges associated with fluorination.
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Asymmetric Catalysis: Science and Opportunities (Nobel Lecture)
TL;DR: Asymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes as discussed by the authors.
Journal ArticleDOI
C-F bond activation in organic synthesis.
Hideki Amii,Kenji Uneyama +1 more
TL;DR: Organic fluorine compounds have received a great deal of interest and attention from the scientists involved in diverse fields of science and technology and not only C-F bond formation but also selective C-f bond activation have become current subjects of active investigation from the viewpoint of effective synthesis of fluoroorganic compounds.