Journal ArticleDOI
Tetraamido-substituted 2,3-naphthalocyanine zinc(II) complexes as phototherapeutic agents: synthesis, comparative photochemical and photobiological studies
S. Müller,Vanya Mantareva,N. Stoichkova,H. Kliesch,Abdol Khezer Sobbi,Dieter Wöhrle,Maria Shopova +6 more
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TLDR
According to all assessment criteria used, the most promising photosensitizer seems to be tetrabenzamido-substituted ZnNc 5, and it is suggested that mainly structural properties are the reason for the better results observed.Abstract:
The aim of this study is to report the synthesis and photochemical and phototherapeutic activities of tetraamido-substituted 2,3-naphthalocyanine zinc(II) complexes (ZnNcs 5-8). Four naphthalocyanine complexes, tetrabenzamido- (ZnNc 5), tetramethoxybenzamido- (ZnNc 6), tetrahexylamido- (ZnNc 7) and tetradodecylamido- (ZnNc 8) naphthalocyanine zinc complexes absorbing at around 770 nm were synthesized. The dye-sensitized photo-oxidation of 1,3-diphenylisobenzofuran via 1O2 was studied in more detail in order to compare the quantum yields of these different sensitizers. Pharmacokinetic and photodynamic therapy studies of Lewis lung carcinoma in mice were carried out after administration of liposome incorporated ZnNcs 5-8. The phototherapeutic efficiency was evaluated by changes in the mean tumour diameter with time, regrowth delay (days), average survival time (days) and electron microscopy observations. According to all assessment criteria used, the most promising photosensitizer seems to be tetrabenzamido-substituted ZnNc 5. We suggest that mainly structural properties are the reason for the better results observed. The morphological analysis confirms the mechanism of photonecrosis, which was observed in our previous work with unsubstituted and substituted ZnNcs 1-4. Direct photodamage to the membrane, mitochondria and rough endoplasmic reticulum in the neoplastic cells and delayed photodestruction of the endothelial cells surrounding the tumour tissue were detected. Also, changes in lysosomes were observed. The data presented through different parameters are compared with such obtained for other photodynamic therapy sensitizers.read more
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A Compilation of Singlet Oxygen Yields from Biologically Relevant Molecules
TL;DR: The purpose of this review was to compile data from many different sources to provide a convenient resource for biological scientists with interest in this area and is essentially an updated subset of the excellent comprehensive review on singlet oxygen yields by Wilkinson et af.
Journal ArticleDOI
Singlet Oxygen Quantum Yields of Different Photosensitizers in Polar Solvents and Micellar Solutions
TL;DR: In this paper, the single oxygen quantum yields of different phthalocyanines and tris(2,2″-bipyridyl)ruthenium(II) dichloride in dimethylformamide (DMF) or aqueous micellar solution of 0.1 M CTAC (cetyltrimethylammonium chloride).
Journal ArticleDOI
Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics
Leanne B. Josefsen,Ross W. Boyle +1 more
TL;DR: The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.
Journal ArticleDOI
Photodynamic Therapy and the Development of Metal-Based Photosensitisers
Leanne B. Josefsen,Ross W. Boyle +1 more
TL;DR: This Review highlights the key photosensitisers investigated, with particular attention paid to the metallated and non-metallated cyclic tetrapyrrolic derivatives that have been studied in vitro and in vivo; those which have entered clinical trials; and those that are currently in use in the clinic for PDT.
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Journal Article
Photodynamic therapy of cancer.
Thomas F. DeLaney,Eli Glatstein +1 more
TL;DR: Clinical trials with hematoporphyrin derivative PDT in the sites mentioned are in progress and laboratory work to better understand HpD also continues, as well as investigations into alternative photosensitizers with improved tumor localization, less cutaneous photosensitivity, and absorption peaks at deeper penetrating wavelengths of light.
Journal ArticleDOI
Silicon naphthalocyanine triplet state and oxygen. A reversible energy-transfer reaction
P. A. Firey,William E. Ford,William E. Ford,James R. Sounik,Malcolm E. Kenney,Michael A. J. Rodgers,Michael A. J. Rodgers +6 more
Journal ArticleDOI
The production of singlet molecular oxygen by zinc(ii) phthalocyanine in ethanol and in unilamellar vesicles. chemical quenching and phosphorescence studies
TL;DR: Zn(II)phthalocyanine (ZnPc) generates O2(1Δg) with a quantum yield of ca.
Journal ArticleDOI
Liposome-delivered Si(IV)-naphthalocyanine as a photodynamic sensitiser for experimental tumours: pharmacokinetic and phototherapeutic studies.
TL;DR: There is substantial evidence that iso-BOSiNc delivered in a liposomal dispersion is a highly effective photosensitizer for PDT of tumours.