The Autism - Tics, AD/HD and other Comorbidities inventory (A-TAC): further validation of a telephone interview for epidemiological research
Tomas Larson,Henrik Anckarsäter,Henrik Anckarsäter,Carina Gillberg,Ola Ståhlberg,Eva Carlström,Björn Kadesjö,Maria Råstam,Paul Lichtenstein,Christopher Gillberg +9 more
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TLDR
Although the A-TAC is principally intended for epidemiological research and general investigations, the instrument may be useful as a tool to collect information in clinical practice as well, and different cut-off levels for screening versus identifying proxies for clinical diagnoses are warranted.Abstract:
Reliable, valid, and easy-to-administer instruments to identify possible caseness and to provide proxies for clinical diagnoses are needed in epidemiological research on child and adolescent mental health. The aim of this study is to provide further validity data for a parent telephone interview focused on Autism - Tics, Attention-deficit/hyperactivity disorder (AD/HD), and other Comorbidities (A-TAC), for which reliability and preliminary validation data have been previously reported. Parents of 91 children clinically diagnosed at a specialized Child Neuropsychiatric Clinic, 366 control children and 319 children for whom clinical diagnoses had been previously assigned were interviewed by the A-TAC over the phone. Interviewers were blind to clinical information. Different scores from the A-TAC were compared to the diagnostic outcome. Areas under ROC curves for interview scores as predictors of clinical diagnoses were around 0.95 for most disorders, including autism spectrum disorders (ASDs), attention deficit/hyperactivity disorder (AD/HD), tic disorders, developmental coordination disorders (DCD) and learning disorders, indicating excellent screening properties. Screening cut-off scores with sensitivities above 0.90 (0.95 for ASD and AD/HD) were established for most conditions, as well as cut-off scores to identify proxies to clinical diagnoses with specificities above 0.90 (0.95 for ASD and AD/HD). The previously reported validity of the A-TAC was supported by this larger replication study using broader scales from the A-TAC-items and a larger number of diagnostic categories. Short versions of algorithms worked as well as larger. Different cut-off levels for screening versus identifying proxies for clinical diagnoses are warranted. Data on the validity for mood problems and oppositional defiant/conduct problems are still lacking. Although the A-TAC is principally intended for epidemiological research and general investigations, the instrument may be useful as a tool to collect information in clinical practice as well.read more
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Examining and interpreting the female protective effect against autistic behavior
Elise B. Robinson,Paul Lichtenstein,Henrik Anckarsäter,Francesca Happé,Angelica Ronald,Angelica Ronald +5 more
TL;DR: Empirical support for the hypothesis of a female protective effect against autistic behavior is provided and can be used to inform and interpret future gene finding efforts in autism spectrum disorders.
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The Swedish Twin Registry : establishment of a biobank and other recent developments
Patrik K. E. Magnusson,Catarina Almqvist,Iffat Rahman,Andrea Ganna,Alexander Viktorin,Hasse Walum,Linda Halldner,Sebastian Lundström,Fredrik Ullén,Niklas Långström,Henrik Larsson,Anastasia Nyman,Clara Hellner Gumpert,Maria Råstam,Henrik Anckarsäter,Sven Cnattingius,Magnus Johannesson,Erik Ingelsson,Lars Klareskog,Ulf de Faire,Nancy L. Pedersen,Paul Lichtenstein +21 more
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Birinder S Cheema,Angelique Houridis,Lisa Busch,Verena Raschke-Cheema,Geoffrey W Melville,Paul W. M Marshall,Dennis Hsu-Tung Chang,Bianca Machliss,Chris Lonsdale,Julia Bowman,Ben Colagiuri +10 more
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The Child and Adolescent Twin Study in Sweden (CATSS).
Henrik Anckarsäter,Sebastian Lundström,Linnea Kollberg,Nóra Kerekes,Camilla Palm,Eva Carlström,Niklas Långström,Patrik K. E. Magnusson,Linda Halldner,Sven Bölte,Christopher Gillberg,Clara Hellner Gumpert,Maria Råstam,Paul Lichtenstein +13 more
TL;DR: Prevalences, distributions, heritability estimates, ages at onset, and sex differences of mental health problems in the CATSS-9/12, were analyzed and found to be overall comparable to those of other clinical and epidemiological studies.
References
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