Journal ArticleDOI
The beta-adrenergic blocking agents and the treatment of glaucoma
TLDR
Data showing a significant reduction in intraocular pressure as a result of ocular instillation of timolol are presented and reduction of the rate of aqueous formation appears to be the mechanism of action.About:
This article is published in Survey of Ophthalmology.The article was published on 1979-05-01. It has received 81 citations till now. The article focuses on the topics: Adrenergic agonist & Autonomic agent.read more
Citations
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Journal ArticleDOI
Pharmacokinetics of topically applied ophthalmic drugs
TL;DR: Pharmacokinetics includes the quantitation of such elements of drug bioavailability as tear dilution, drug binding, and vehicle effects; factors affecting corneal absorption and subsequent tissue distribution; dosage form effects; and pathways of elimination.
Journal ArticleDOI
Pharmacogenetics of β-Blockers
Jaekyu Shin,Julie A. Johnson +1 more
TL;DR: In this article, a review summarizes the pharmacogenetic data for β-blockers in patients with various diseases and discusses the potential implications of βblocker pharmacogenetics in clinical practice.
Journal ArticleDOI
Ocular beta-blockers in glaucoma management. Clinical pharmacological aspects.
TL;DR: Because of the lower risk of precipitating side effects, betaxolol is probably the beta-blocker of first choice for use in glaucoma; timolol or levobunolol are reserved for patients who do not respond satisfactorily to betaxOLol and are quite free of respiratory disease.
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Drug delivery by contact lens in spontaneously glaucomatous dogs.
TL;DR: Ophthalmic drug delivery through contact lenses increases bioavailability and reduces systemic drug uptake, suggesting higher bioavailability for contact lenses compared to eye drops.
Journal ArticleDOI
The pharmacology of antiglaucoma drugs.
TL;DR: Dynamique de l'humeur aqueuse et de the penetration oculaire des medicaments, d'anhydrase carbonique, eicosanoides, etc…
References
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Journal ArticleDOI
A study of the adrenotropic receptors
TL;DR: Experiments described in this paper indicate that although there are two kinds of adrenotropic receptors they cannot be classified simply as excitatory or inhibitory since each kind of receptor may have either action depending upon where it is found.
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Differentiation of receptor systems activated by sympathomimetic amines.
TL;DR: The classification of receptor systems which are activated by sympathomimetic amines has engaged the attention of many investigators as mentioned in this paper, who have suggested the convenient designations of alpha (α) and beta (β) to distinguish major differences in the responses elicited in various organ systems.
Journal ArticleDOI
On some physiological actions of ergot.
TL;DR: The facts make it impossible to speak of the action any longer as that of chrysotoxin, as the introduction of new names on the strength of physiological results, and in default of chemical isolation of principles, would inevitably add to the existing confusion.
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On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari
TL;DR: It is shown that niicotine stimulates symnpathetic nerve cells by a direct action upon thetn, and reasons for thinking that it does not stinmulate pre-ganglionic nierve-endings, and that nicotine can paralyse nerve cells as regards stimulation by nicotine.