Journal ArticleDOI
The chemistry of a 1,5-diblocked flavin. 2. Proton and electron transfer steps in the reaction of dihydroflavins with oxygen
Gert Eberlein,Thomas C. Bruice +1 more
TLDR
In this paper, a determination des potentiels de reduction d'isoalloxazines en fonction du pH, par voltammetrie cyclique sur couche mince.Abstract:
Determination des potentiels de reduction d'isoalloxazines en fonction du pH, par voltammetrie cyclique sur couche mince. Etude de l'oxydation par O 2 de dihydro-1,5 lumiflavines disubstituees-1,5read more
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Journal ArticleDOI
Activation of molecular oxygen by flavins and flavoproteins.
TL;DR: Clearly the reactivity of the reduced flavin with 0, is modulated by the protein environment in which i t is located, both in terms of rates and products of the reaction.
Journal ArticleDOI
Tetrahydropterin-dependent amino acid hydroxylases.
TL;DR: Reversible phosphorylation of serine residues in the regulatory domains affects the activities of all three enzymes, and phenylalanine hydroxylase is allosterically regulated by its substrates, phenylAlanine and tetrahydrobiopterin.
Journal ArticleDOI
Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes
TL;DR: The state of the art on a key area of research in flavin enzymology: the molecular basis for the activation of O2 by flavin-dependent oxidases and monooxygenases is summarized.
Journal ArticleDOI
The enigmatic reaction of flavins with oxygen
TL;DR: It is shown that the spatial arrangement of the reacting oxygen that is in direct contact with the flavin group is emerging as a crucial factor that differentiates between oxidase and monooxygenase enzymes.
Journal ArticleDOI
Catalysis of electron transfer during activation of O2 by the flavoprotein glucose oxidase
TL;DR: Site-directed mutagenesis studies reveal that the pH dependence of the rates is caused by protonation of a highly conserved histidine in the active site, and an explanation is advanced based on changes in outer-sphere reorganization as a function of pH.