Journal ArticleDOI
The Diabetes Control and Complications Trial (DCCT). A milestone in diabetes management.
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This article is published in The Medical Journal of Australia.The article was published on 1993-12-06. It has received 17 citations till now. The article focuses on the topics: Diabetes management & Milestone (project management).read more
Citations
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Elevated triglycerides correlate with progression of diabetic neuropathy
Timothy D. Wiggin,Kelli A. Sullivan,Rodica Pop-Busui,Antonino Amato,Anders A. F. Sima,Eva L. Feldman +5 more
TL;DR: In this cohort of participants with mild to moderate diabetic neuropathy, elevated triglycerides correlated with MFD loss independent of disease duration, age, diabetes control, or other variables support the evolving concept that hyperlipidemia is instrumental in the progression of diabetic Neuropathy.
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Inflammation as a Therapeutic Target for Diabetic Neuropathies.
TL;DR: Current evidence regarding the role of low-grade inflammation as a potential therapeutic target for diabetic neuropathies is summarized.
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Mediators of Lifestyle Behavior Change in Native Hawaiians: Initial findings from the Native Hawaiian Diabetes Intervention Program
TL;DR: The initial findings suggest that stage of change is an important factor in mediating lifestyle behavior changes in persons with or at risk for diabetes and merits further study among minority populations at highrisk for diabetes.
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The Genetics of Diabetic Nephropathy
TL;DR: The merits of employing an integrative approach to incorporate datasets from multiple sources in order to fully elucidate the genetic elements contributing to this serious complication of diabetes are discussed.
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Bioenergetics in diabetic neuropathy: what we need to know.
TL;DR: This review identifies weaknesses in the understanding of diabetes‐disordered metabolism in the neurovascular unit, that is, in critical cell types of the microvascular endothelium, peripheral sensory neurons, and supporting Schwann cells.
References
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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.
Diabetes Control,David M. Nathan,Saul M. Genuth,John M. Lachin,Patricia A. Cleary,O Crofford,Matthew M. Davis,Larry Rand,Carolyn Siebert +8 more
TL;DR: Intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy, nephropathy, and neuropathy in patients with IDDM.
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The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus.
TL;DR: Long-term intensified insulin treatment, as compared with standard treatment, retards the development of microvascular complications in patients with insulin-dependent diabetes mellitus.
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Diabetes Control and Complications Trial. Position statement of the Australian Diabetes Society.
TL;DR: Analysis of the data does not support the existence of a specific target value for HbA1c at which the benefits of intensive therapy are maximised and the risks minimised, and the position of the Australian Diabetes Society is as follows.
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UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance.
R. C. Turner,Rury R. Holman,David R Matthews,S. Oakes,P A Bassett,Irene M Stratton,Carole A. Cull,Susan E. Manley,Frighi +8 more
TL;DR: The UK Prospective Diabetes Study is a multi-centre, prospective, randomised, intervention trial of 5100 newly-diagnosed patients with Type 2 (non-insulin-dependent) diabetes mellitus which aims to determine whether improved blood glucose control will prevent complications and reduce the associated morbidity and mortality.
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Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes
TL;DR: Long-term intensive blood glucose control significantly reduces the risk of diabetic retinopathy and nephropathy progression but long-term continuous subcutaneous insulin infusion was associated with an increased incidence of diabetic ketoacidosis, and intensive therapy may cause more severe hypoglycaemic reactions.