Journal ArticleDOI
The effect of atropine and curarine on the time course of the end-plate potential in frog sartorius muscle
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The effect of atropine and curarine on the time course of the end-plate potential was studied in the presence and absence of anticholinesterases in curarized muscle to find out whether a late component of transmitter action is suppressed.About:
This article is published in Neuropharmacology.The article was published on 1968-11-01. It has received 36 citations till now. The article focuses on the topics: End-plate potential.read more
Citations
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Journal ArticleDOI
Factors affecting the time course of decay of end‐plate currents: a possible cooperative action of acetylcholine on receptors at the frog neuromuscular junction.
Karl L. Magleby,D. A. Terrar +1 more
TL;DR: It is suggested on the basis of the observations described in paragraphs 6 to 8 that the time constant of decay of end‐plate currents in the presence of prostigmine increases with increasing concentrations of ACh in the synaptic cleft.
Journal ArticleDOI
The effect of procaine on neuromuscular transmission.
TL;DR: The mechanism of procaine action on post‐synaptic receptors for acetylcholine was studied by recording the end‐plate current at membrane potentials ranging from about +30 to about −140 mV.
Book ChapterDOI
Transmission of Impulses from Nerve to Muscle
B. L. Ginsborg,D. H. Jenkinson +1 more
TL;DR: In this chapter neuromuscular transmission will be discussed mainly from an electrophysiological standpoint although some specifically pharmacological topics, in particular the properties of the acetylcholine receptors, will also be considered.
Journal ArticleDOI
Analysis of atropine action at the frog neutromuscular junction.
Anne Feltz,W A Large,A Trautmann +2 more
TL;DR: It is suggested that atropine binds to the open acetylcholine‐receptor complex, leading to a state with a null conductance, and another binding occurring before the channel is open with a dissociation constant of 60 micrometer could account for this effect.
Journal ArticleDOI
A comparison of the effect of cholinesterase inhibitors on end-plate current and on cholinesterase activity in frog muscle.
M. Kordas,Miro Brzin,Živa Majcen +2 more
TL;DR: The changes in the end-plate current, observed at a relatively high concentration of reversible inhibitors, are thought to be related either to a presynaptic, or to a postsynaptic “curare-like” action of these drugs.
References
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Journal ArticleDOI
An analysis of the end‐plate potential recorded with an intra‐cellular electrode
P. Fatt,Bernard Katz +1 more
TL;DR: The immediate concern of the present work is to determine the electric charge which passes through the end-plate membrane during the transmission of one impulse and to throw some light on the mechanism by which the transfer of ions across theend-plate is brought about.
Journal ArticleDOI
Observations on the isolated phrenic nerve diaphragm preparation of the rat
TL;DR: Edith Bulbring developed the isolated phrenic nerve-diaphragm strip preparation of the rat in order to determine whether any of the complex effects of adrenaline on contractions might be secondary to an action on the muscle blood flow, which was the first mammalian isolated nerve-skeletal muscle preparation to be described.
Journal ArticleDOI
On the localization of acetylcholine receptors.
J. del Castillo,Bernard Katz +1 more
TL;DR: The evidence supports the view that specific chemoreceptors are located on the external surface of the end-plate, that is on the side of the muscle membrane which makes contact with the nerve endings, while the internal surface of that membrane is insensitive to applied ACh.
Journal ArticleDOI
Active phase of frog's end-plate potential.
Akira Takeuchi,Noriko Takeuchi +1 more
TL;DR: The purpose of the present experiment was to determine directly the time course of the active phase of the e.
Journal ArticleDOI
Reactions of denervated voluntary muscle, and their bearing on the mode of action of parasympathetic and related nerves
H. H. Dale,J. H. Gaddum +1 more
TL;DR: The recent careful review by Gasser of work on these contracture responses of denervated muscles makes it unnecessary for us to give a connected historical survey; the authors need only refer, in their proper places, to earlier observations bearing on their own.
Related Papers (5)
Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction
The binding of acetylcholine to receptors and its removal from the synaptic cleft
Bernard Katz,Ricardo Miledi +1 more