Showing papers in "Neuropharmacology in 1968"

TL;DR: A method for the determination of both serotonin (5HT) and norepinephrine (NE) in small samples of brain is described, applicable to as little as 50 mg of brain tissue.

TL;DR: The similarity between the DA-effect and cationic (hyperpolarizing) current, the antagonistic effect of glutamate and anionicCurrent, the differences compared to procaine-induced inhibition, seem to indicate that in the inhibitory effect of DA repolarization (or hyperpolarization) of the cell membrane is involved.

TL;DR: The site of action of ketamine in minimal anesthetic doses appears to be in the non-specific thalamo-neocortical system, which seems to be a primary factor in producing the hypersynchronous delta wave burst pattern in the EEG.

TL;DR: Cortisone treatment during acquisition resulted in a decrease in intertrial goal-directed activity without affecting the acquisition of the avoidance response, whilst Adrenalectomy performed 1 day prior to conditioning brought about an enhancement of intertrial activity, whilst no changes in avoidance acquisition were observed when the rats were maintained on saline or DOCA treatment.

TL;DR: This method was employed to examine the relationship between behaviour, electrocortical activity and cortical acetylcholine output in conscious, freely moving animals to assess the impact of drugs on the activity of cholinergic pathways belonging to the reticulocortical ascending system.

TL;DR: It is concluded that muscarinic stimulation of the central nervous system causes catalepsy and can cause hypothermia; and catalEPsy and Hypothermia are independent phenomena.

TL;DR: The findings presented in this paper support the concept of cholinergic synaptic transmission in the cerebellar granule cell layer.

TL;DR: The drugged animals showed improved learning of the two-way problem, reaching criterion in one-half the number of trials and making one-third as many errors as the saline injected controls.

TL;DR: AF 1161 possesses a very slight anti-histamine action, a moderate adrenolytic action and a powerful anti-serotonin action, and possible therapeutic use in man of AF 1161 is postulated.

TL;DR: Improvement of avoidance acquisition by a single injection of ACTH was found in the early phase of conditioning in intact and adrenalectomized rats treated with short-acting ACTH for 14 days.

TL;DR: It has been verified that the analgesic response to morphine was abolished 4 hr after the injection of a single dose of reserpine in rabbits as well as in mice; in rabbits this response gradually recovered and the possible role of catecholamines and serotonin in morphine analgesia was discussed.

TL;DR: Most of the behavioral effects of physostigmine are related to central AChE inhibition, suggesting a central site of action.

TL;DR: Intraventricular injections of triethylcholine made in conscious rats produced catatonia preceded in a number of animals by a seizure and hemicholinium-3 also produced a brief period of cat atonia but any seizures which occurred did so only after an interval of about 1 hr.

TL;DR: The data show that the lipolytic response is under the direct control of nerve fibers which are functionally sympathetic, since this response can be modified by a wide variety of compounds which are known to influence sympathetic activity both at the neuro-effector junction and at the postjunctional sites of hormonal action.

TL;DR: An effort has been mad to correlate the rate of increase in catechol and indole amines with maturation and with the physiological, morphological and functional integration of the CNS.

TL;DR: The effect of atropine and curarine on the time course of the end-plate potential was studied in the presence and absence of anticholinesterases in curarized muscle to find out whether a late component of transmitter action is suppressed.

TL;DR: Neither amphetamine nor caffeine increased Y-maze activity at doses which increased locomotor wheel activity, but methylphenidate greatly increased activity in the Y-Maze indicating a qualitative difference in the effects of this drug.

TL;DR: The experimental group and the Reactive strain performed significantly better than their controls; these results are seen as support for the neural consolidation hypothesis.

TL;DR: It appears that the levels of acetylcholinc and its actions on “muscarinic” receptors are critical in influencing hippocampal function, and these local cholinergic systems in the hippocampus might then be expected to assume special significance in normal and abnormal brain activities.

TL;DR: In rats, small doses of chlorpromazine cause a decrease in gross behavior and motor activity which is readily reversible by D-amphetamine, but can be reversed by the combination ofD-amphetamine and cholinergic blocking agents such as atropine.

TL;DR: It is concluded that Nitrazepam reduces the sensory input to the hippocampal formation by specifically depressing the projection systems for afferent sensory information by effectively counteracted by acetylcholine microelectrophoresis.

TL;DR: The anticataleptic activity of seopolamine and amphetamine was compared in a group of ten rats with a permanent catatonic state induced by large electrolytic lesions directed to the posterior hypothalamus.

TL;DR: It is concluded that blockade of central cholinergic synapses was responsible for both effects and there is some discussion of the significance of the system involved in EEG arousal.

TL;DR: The technique of power spectrum analysis was used to study the effects of drugs on the ECoG of the cat by comparing pentobarbital and methyprylon and chlorpromazine, diazepam and three other benzodiazepines.

TL;DR: It is suggested that the central vagal, and perhaps also the central vasomotor, mechanism contains at least one cholinergic synapse which is blocked by intraventricular l -hyoscyamine or ethybenztropine.

TL;DR: In lightly anaesthetized rats, a microinjection of chlorpromazine into the anterior part of the hypothalamus or into the third ventricle, but not into other parts of the brain, caused a long lasting rise in body temperature.

TL;DR: The rates of uptake and disappearance indicate that methionine possibly interferes with the influx as well as the efflux of label at the cell membrane, and that l -tryptophan exhibited some impairment on the uptake of labeled 5-HTP by brain in vivo.

TL;DR: It was found that at room temperature 20 min after treatment, aggregation reduced the response for C3H mice particularly when compared with the control, thus showing a strong genetic influence.

TL;DR: Facilitatory and depolarizing drugs both produce facilitation of the cat skeletal muscle, and antidromic firing in the motor nerve following an orthodromic stimulus, which is explained on the basis of two cholinoceptive sites on the Motor nerve terminal.

TL;DR: It is suggested that depletion of brain norepinephrine and/or dopamine is an important factor in the ECoG effect of αMT and reserpine and that pretreatment with pheniprazine antagonized the voltage increase.