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Journal ArticleDOI

The effect of prostaglandin E1 on platelet function in vitro and in vivo.

TLDR
It is concluded that the effect of PGE1 on haemostasis involves inhibition of the release of ADP from platelets exposed to collagen and thrombin, and inhibition ofADP‐induced aggregation.
Abstract
Summary Low concentrations of prostaglandin E1 (PGE1) inhibit ADP-induced aggregation in pig and rabbit citrated platelet-rich plasma and in suspensions of washed platelets. Higher concentrations also inhibit the initial change in shape induced by ADP and the release of platelet ATP, ADP and serotonin caused by stimuli such as collagen, thrombin, antigen-antibody complexes and gamma-globulin-coated polystyrene particles. PGE1 is not taken up by platelets and its effects can be removed by resuspending platelets in fresh medium. Immediately following an intra-arterial injection, ADP-induced platelet aggregation is suppressed, but after 5 min the response returns to normal. PGE1 inhibits haemostasis in rabbits when given as a continuous infusion. It is concluded that the effect of PGE1 on haemostasis involves inhibition of the release of ADP from platelets exposed to collagen and thrombin, and inhibition of ADP-induced aggregation.

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Опыт применения алпростадила при синдроме Рейно у детей

I. Alekseyeva
TL;DR: The data provides information on the causes andMechanisms of Raynaud's SYNDROME development, as well as the take-up of some MEDICATIONS.
Journal ArticleDOI

Preservación prolongada del pulmón para el trasplante pulmonar

TL;DR: En this trabajo se presentan las tecnicas de preservacion del injerto y los metodos para detectar la viabilidad pulmonar tras the preservación.
Journal ArticleDOI

Beeinflussung der Biosynthese der Eicosanoide durch die Ernährung‐ Klinische Konsequenzen

TL;DR: Dietary measures allow to manipulate the eicosanoid profile, and to treat diseases with disturbed eicOSanoid biosynthesis.
Journal ArticleDOI

Experimental study on disseminated intravascular coagulation (DIC)

TL;DR: The results indicated that aggravations of blood parameters and pathological findings were dependent upon the dose of ET, and Group III made the highest score in on studies, which may conclude that Group III was considered to be useful as DIC model in rabbits.
References
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Journal ArticleDOI

Prostaglandins: Their Disappearance from and Release into the Circulation

TL;DR: The liver and lungs provide an efficient protective mechanism to remove almost all the prostaglandin before it reaches the arterial circulation.
Journal ArticleDOI

Adenosine diphosphate-induced platelet aggregation in suspensions of washed rabbit platelets.

TL;DR: On comparison with rabbit platelets prepared from blood taken into EDTA, the only differences observed were the much greater sensitivity to ADP and a higher calcium content; platelet morphology, nucleotide levels, and conversions of 14C‐ATP and 14C-ADP at the platelet membrane were similar.
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