Journal ArticleDOI
The effect of prostaglandin E1 on platelet function in vitro and in vivo.
TLDR
It is concluded that the effect of PGE1 on haemostasis involves inhibition of the release of ADP from platelets exposed to collagen and thrombin, and inhibition ofADP‐induced aggregation.Abstract:
Summary Low concentrations of prostaglandin E1 (PGE1) inhibit ADP-induced aggregation in pig and rabbit citrated platelet-rich plasma and in suspensions of washed platelets. Higher concentrations also inhibit the initial change in shape induced by ADP and the release of platelet ATP, ADP and serotonin caused by stimuli such as collagen, thrombin, antigen-antibody complexes and gamma-globulin-coated polystyrene particles. PGE1 is not taken up by platelets and its effects can be removed by resuspending platelets in fresh medium. Immediately following an intra-arterial injection, ADP-induced platelet aggregation is suppressed, but after 5 min the response returns to normal. PGE1 inhibits haemostasis in rabbits when given as a continuous infusion. It is concluded that the effect of PGE1 on haemostasis involves inhibition of the release of ADP from platelets exposed to collagen and thrombin, and inhibition of ADP-induced aggregation.read more
Citations
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Journal ArticleDOI
Human platelet PGE1 and dihomogammalinolenic acid. Comparison to PGE2 and arachidonic acid
Journal ArticleDOI
The synthesis of prostaglandins in human platelets.
J. Clausen,K. C. Srivastava +1 more
TL;DR: Human blood platelets were found to possess the whole biological system for synthesis of prostaglandins from C14-labeled acetate and inherent derivatives of essential fatty acids, and the results obtained were related to the theory of the inhibiting function of prostagslandins on the platelet agglutination.
Journal ArticleDOI
Metabolic disposition of prostaglandin E1 in man
TL;DR: Radioactivity in plasma rapidly declined during the first 10 min after termination of the infusion, and then was eliminated exponentially with a mean half-life of 181 min, probably reflecting slow excretion of one or more metabolite.
Journal ArticleDOI
Basal level of human platelet prostaglandins: PGE1 is more elevated than PGE2.
TL;DR: Radioimmunoassays of platelet prostaglandins E1 and F1 alpha in platelet rich plasma or platelet suspension, demonstrate that both PGE1 and PGF1 alpha are present at higher concentrations than prostag landins E2 and F2 alpha.
Journal ArticleDOI
The effects of OP-1206 α-CD on walking dysfunction in the rat neuropathic intermittent claudication model
Katsuhiko Nakai,Yoshifumi Takenobu,Kazuhide Eguchi,Hideyuki Takimizu,Kaneyoshi Honjo,Shinji Akimaru,Hitoshi Maegawa,Martin Marsala,Nobuo Katsube +8 more
TL;DR: Data show that oral treatment with OP-1206 α-CD is effective in improving walking dysfunction induced by spinal canal stenosis, and this therapeutic effect is likely mediated by improved SCBF at the territory of spinal stenosis.
References
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Journal ArticleDOI
Prostaglandins: Their Disappearance from and Release into the Circulation
S. H. Ferreira,John R. Vane +1 more
TL;DR: The liver and lungs provide an efficient protective mechanism to remove almost all the prostaglandin before it reaches the arterial circulation.
Journal ArticleDOI
Adenosine diphosphate-induced platelet aggregation in suspensions of washed rabbit platelets.
TL;DR: On comparison with rabbit platelets prepared from blood taken into EDTA, the only differences observed were the much greater sensitivity to ADP and a higher calcium content; platelet morphology, nucleotide levels, and conversions of 14C‐ATP and 14C-ADP at the platelet membrane were similar.