The effect of vitamin D on renal inorganic phosphate reabsorption of normal rats, parathyroidectomized rats, and rats with rickets.
D. Gekle,J. Ströder,D. Rostock +2 more
TLDR
In animals under a phosphate load who suffered from rickets, it was possible to normalize the decreased rate of reabsorption of phosphate by the administration of vitamin D, and showed that vitamin D exerted a direct effect on transtubular re absorption of phosphate that was independent of parathyroid function.Abstract:
The Effect of Vitamin D on Renal Inorganic Phosphate Reabsorption of Normal Rats, Parathyroidectomized Rats, and Rats with Ricketsread more
Citations
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Evidence for a Direct Action of Cholecalciferol and 25-Hydroxycholecalciferol on the Renal Transport of Phosphate, Sodium, and Calcium
TL;DR: These observations provide the first conclusive evidence for a direct (proximal) tubular action of vitamin D to promote phosphate (as well as sodium and calcium) transport.
Journal ArticleDOI
Site of 1,25(OH)2 vitamin D3 synthesis in the kidney.
TL;DR: Using single nephron preparations, it is demonstrated that the major and probably exclusive site of synthesis of 1,25(OH)2D3 is the proximal tubule.
Journal ArticleDOI
Influence of dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rat.
T H Steele,H F DeLuca +1 more
TL;DR: Dietary phosphorus-dependent alterations in Pi reabsorption may play a significant role in establishing the rate of Pi excretion per nephron under certain circumstances and should be considered in the interpretation of studies investigating renal Pi handling.
Journal ArticleDOI
Physiology of the Kidney and Body Fluids.
TL;DR: The second edition of Pitts' popular book on renal physiology continues to be the best presentation of the subject presently available and to present a number of highly questionable assertions.
Journal ArticleDOI
Excretion of Phosphate and Calcium: Physiology of Their Renal Handling and Relation to Clinical Medicine
TL;DR: The effects of changes in glomerular filtration rate, renal vasodilatation, extracellular fluid volume expansion, diuretics, state of body stores of phosphate, acid-base status, diet, and various hormones are discussed.
References
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MEASUREMENT OF GLOMERULAR FILTRATION-RATE IN MAN USING A 51Cr/EDETIC-ACID COMPLEX
TL;DR: Equilibration with interstitial fluid in non-œdematous patients takes less than 2 hours and there is no detectable extrarenal uptake so that the " slope " method based on 2-4-hour plasma-activity measurements can be used as a simple routine procedure.
Journal ArticleDOI
The renal excretion of inorganic phosphate in relation to the action of vitamin d and parathyroid hormone.
Journal ArticleDOI
Micropuncture study of inorganic phosphate excretion in the rat.
James Strickler,David D. Thompson,RM Klose,Gerhard Giebisch,Judith N. Gluck,Judith B. Vaughan +5 more
TL;DR: Several investigators have proposed that inorganic phosphate may also be secreted into the mammalian tubule, and Nicholson and Shepherd have interpreted their data in favor of distal tubular secretion of this ion species in the dog, since they were able to suppress urinary phosphate excretion subsequent to selective toxic damage of the distal tube.
Journal ArticleDOI
Physiology of the Kidney and Body Fluids.
TL;DR: The second edition of Pitts' popular book on renal physiology continues to be the best presentation of the subject presently available and to present a number of highly questionable assertions.