Journal ArticleDOI
The effects of quipazine on serotonin metabolism in rat brain.
Ray W. Fuller,Harold D. Snoddy,Kenneth W. Perry,Betty W. Roush,Bryan B. Molloy,Frank P. Bymaster,David T. Wong +6 more
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TLDR
Quipazine reversibly inhibited the oxidation of serotonin by rat brain monoamine oxidase invitro and protected against the irreversible inactivation of the enzyme invivo, but did not prevent the depletion of brain serotonin by p-chloroamphetamine invivo.About:
This article is published in Life Sciences.The article was published on 1976-05-01. It has received 71 citations till now. The article focuses on the topics: Quipazine & Serotonin uptake.read more
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Serotonin and alcohol intake, abuse, and dependence: Findings of animal studies.
TL;DR: It is concluded that serotonin mediates ethanol intake as a part of its larger role in behavior modulation, such that increases in serotonergic functioning decrease ethanol intake, and decreased serotonergy functioning increases ethanol intake.
REVIEW ARTICLE Serotonin and Alcohol Intake, Abuse, and Dependence: Findings of Animal Studies
TL;DR: In this article, the effects of serotonergic manipulations on the intake of alcohol, and the effect of acute and chronic alcohol intake, as well as the withdrawal of chronic alcohol, on the Serotonergic system were investigated.
Journal ArticleDOI
Dominant social status facilitates the behavioral effects of serotonergic agonists
Michael J. Raleigh,Michael J. Raleigh,Gary L. Brammer,Gary L. Brammer,Michael T. McGuire,Michael T. McGuire,Arthur Yuwiler,Arthur Yuwiler +7 more
TL;DR: The effects of dominance rank on the behavioral responses to drugs that enhance central serotonergic function were examined in 45 adult male vervet monkeys and suggest that dominant and subordinate males differ in the drug sensitivity of theirserotonergic systems.
Journal ArticleDOI
Serotonin-releasing effects of substituted piperazines in vitro
TL;DR: These studies show that several piperazine-containing compounds can evoke a potent release of endogenous stores of hypothalamic 5-HT in vitro, actions which should be considered together with their direct agonist activity when interpreting the CNS effects in vivo.
Journal ArticleDOI
Pharmacology of central serotonin neurons.
TL;DR: Drugs with improved potency and specificity are becoming available for the pharmacologic manipulation of serotonin neurons in brain and have real or potential value in the treatment of diseases like mental depression, obesity, myoclonus, pain, hypertension, and endocrine dysfunction.
References
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Journal ArticleDOI
Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase.
TL;DR: The accumulation of DOPA and 5-HTP in rat brain after decarboxylase inhibition with NSD 1015 appears to be a reliable measure of the in vivo hydroxylation of tyrosine and tryptophan.
Journal Article
A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy). N-methyl-3-phenylpropylamine.
TL;DR: Lilly 110140 is a potent and selective inhibitor for uptake of 5-HT into synaptosomes of rat brain and its primary amine derivative did not block the in vivo uptake of NE into rat heart.
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Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid☆
TL;DR: The time-course of effects of a single dose of p -chlorophenylanine on rat brain amines shows a significant lowering of serotonin (5HT) and 5-hydroxyindole-3-acetic acid (5HIAA) beginning on day 1 and lasting for about 8 days.
Journal ArticleDOI
Effect of an uptake inhibitor on serotonin metabolism in rat brain: Studies with 3-(p-trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine (Lilly 110140)
TL;DR: Lilly 110140 had no effect on brain levels of tryptophan, serotonin, dopamine, or norepinephrine, but it decreased 5-hydroxyindoleacetic acid (5HIAA) levels, and reduced turnover was indicated by a decreased rate of fall in brain serotonin levels after p-chlorophenylalamine was given to inhibit serotonin synthesis.
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Serotonin-like actions of quipazine on the central nervous system.
TL;DR: Evidence presented in this study suggests that the central actions of quipazine may be due to activation of serotonergic processes, which is similar to those induced by the serotonin precursor.