Journal ArticleDOI
[The elimination of hydroxyethyl starch 200/0.5, dextran 40 and oxypolygelatine (author's transl)].
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The greatest renal clearance was found for oxypolygelatine, which showed a close relation to the molecular weight, and a rapid elimination simultaneously is followed by a correspondingly lower volume effect.Abstract:
After withdrawal of 400 ml whole blood and subsequent infusion of 500 ml of a colloidal plasma substituent, the intravascular and renal colloid elimination was investigated in 40 test subjects. The individual colloidal solutions could no longer be demonstrated in the intravascular space after the following times: 10% hydroxyethyl starch 200/0.5 (anthrone method) after six weeks, 10% dextran 40 (anthrone method) after two weeks, 6% hydroxyethyl starch 200/0.5 (anthrone method) after four weeks and 5.5% oxypolygelatine (hydroxyproline method) after two days. Colloidal plasma substitutes are polydisperse solutions with various molecular weights and degree of hydroxyethylation and therefore, also have a large number of different elimination constants. With repeated application, the intravascular colloid concentration shifts in favour of the molecules with a longer half life which are difficult to eliminate. The elimination of the clinically employed dextran 40 and oxypolygelatine solution could be best described with an open two-compartment model. As a result of its greater heterogeneity, the elimination of the moderately high molecular weight hydroxyethyl starch 200/0.5 could only be characterized approximately even assuming three elimination constants. In the first four days, the hydroxyethyl starch 200/0.5 was more rapidly eliminated compared to dextran 40. However, subsequently a very much lower elimination from the intravascular space was found for about 3% of the administered hydroxyethyl starch 200/0.5. Oxypolygelatine was eliminated especially rapidly. Accordingly, the greatest renal clearance was found for oxypolygelatine, which showed a close relation to the molecular weight. On the other hand, a rapid elimination simultaneously is followed by a correspondingly lower volume effect.read more
Citations
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Journal ArticleDOI
Pharmacokinetics of Hydroxyethyl Starch
TL;DR: Prolonged persistence of hydroxy methyl starch in plasma and tissues can be avoided by using rapidly metabolisable hydroxyethyl starch types with molar substitution <0.5, and no adverse effects on kidney function have been observed even with large repetitive doses when used according to the product information.
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Dextran-70 versus albumin as plasma expanders in cirrhotic patients with tense ascites treated with total paracentesis. Results of a randomized study.
Ramon Planas,Pere Ginès,Vicente Arroyo,Josep Llach,Julià Panés,Victor Vargas,Joan Manel Salmeron,Angels Ginès,C. Toledo,Antoni Rimola,Wladimiro Jiménez,M. Asbert,Miquel A. Gassull,Joan Rodés +13 more
TL;DR: In this paper, the effect of paracentesis on effective intravascular volume was indirectly assessed by measuring plasma renin activity and aldosterone concentration before and 2 and 6 days after treatment, the patients being without diuretics.
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Dextran prodrugs — structure and stability in relation to therapeutic activity
TL;DR: The utility of various drug fixation methods to provide well-defined dextran-drug conjugates with feasible delivery characteristics is discussed and it is emphasized that adequate characterization of the prepared deXTran prodrugs prior to biological evaluation is of the utmost importance.
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Synthetic plasma volume expanders--their pharmacology, safety and clinical efficacy.
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Pharmacokinetics and Tolerability of a New Hydroxyethyl Starch (HES) Specification [HES (130/0.4)] after Single-Dose Infusion of 6% or 10% Solutions in Healthy Volunteers.
Josef Waitzinger,Frank Bepperling,Günther Pabst,Jens Opitz,Margarete Müller,Jean François Baron +5 more
TL;DR: The new HES specification demonstrated favourable pharmacokinetic properties compared with other HES specifications of medium or high molecular weight.
References
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Journal ArticleDOI
Determination of hydroxyproline.
TL;DR: A critical review is given of hydroxyproline analysis, finding a procedure which is faster and more sensitive than the former one and as reliable.
Journal ArticleDOI
[Microdetermination of hydroxyproline with chloramine-T and p-dimethylaminobenzaldehyde].
Journal ArticleDOI
The renal clearance of dextran of different molecular sizes in normal humans.
G. Arturson,G. Wallenius +1 more
TL;DR: In this article, the Renal Clearance of Dextran of Different Molecular Sizes in Normal Humans in Normal humans is discussed. But this paper is limited to the case of normal humans.
Journal ArticleDOI
Intravascular persistence of hydroxyethyl starch in man
TL;DR: The hypothesis that HES infusion causes and augmentation of serum alpha-amylase concentrations in man was confirmed and should be borne in mind when HES solutions are given to patients in whom the diagnosis of acute pancreatitis might be considered.