The facile synthesis of unsymmetrical ketones using acetone dimethylhydrazone
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Unsymmetrical ketones were prepared by successive alkylation of acetone dimethylhydrazone in this article, and application of this reaction to the synthesis of dihydrojasmone was described.Abstract:
Unsymmetrical ketones were prepared by successive alkylation of acetone dimethylhydrazone. Application of this reaction to the synthesis of dihydrojasmone is described.read more
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Book ChapterDOI
Alkylations of Enols and Enolates
TL;DR: The α-alkylation of carbonyl compounds by their conversion into nucleophilic enolates or enolate equivalents and subsequent reaction with electrophilic alkylating agents provides one of the main avenues for regio-and stereo-selective formation of carbon-carbon σ-bonds as mentioned in this paper.
Book ChapterDOI
Synthesis and structure-activity relationships of peroxidic antimalarials based on artemisinin
TL;DR: With a dataset of over 200 artemisinin analogues, various comparative molecular field analysis (CoMFA) pharmacophore models have been developed based on the conformational hypotheses that the active conformation of the analogues is the globally minimized structure.
Journal ArticleDOI
α, β-epoxy sulfoxides as useful intermediates in organic synthesis. I: A novel synthesis of dialkyl ketones and a synthesis of aldehydes from ketones by one carbon elongation
TL;DR: In this paper, the mechanism of this reaction and an application of this process to a formal total synthesis of dihydrojasmone are described, as well as an application to the full synthesis of the dihydronemone.
Journal ArticleDOI
A Convenient Synthesis of Diketones via Alkylation of Alkyl Methyl Ketone Dimethylhydrazones
TL;DR: Symmetrical diketones were prepared by the reaction of the lithium salts of alkyl methyl ketone dimethylhydrazones with dibromoalkanes as mentioned in this paper.
References
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Journal ArticleDOI
Herstellung und synthetische Verwendung von metallierten Dimethylhydrazonen Regio‐ und stereoselektive Alkylierung von Carbonylverbindungen
E. J. Corey,Dieter Enders +1 more
TL;DR: Dimethylhydrazone (DMH's) 6−10 von enolisierbaren Aldehyden und Ketonen konnen with n-Butyllithium and/oder Lithium-diisopropylamid in Tetrahydrofuran quantitativ in α-Stellung metalliert werden as mentioned in this paper.
Journal ArticleDOI
Synthesewege zu polyfunktionellen Molekülen über metallierte Dimethylhydrazone
E. J. Corey,Dieter Enders +1 more
TL;DR: In this article, metallated dimethylhydrazones (DMH's) with electrophiles such as saturated and α,β-unsaturated carbonyl compounds and oxiranes are used to effect overall regiospecific CC bond formation in the α-position to a carbonyll group.
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