The genetic covariance between characters maintained by pleiotropic mutations
TLDR
Approximate expressions for the dynamics of the genetic covariances due to pleiotropic mutations are obtained and patterns of genetic covariance between characters and their evolution are discussed with reference to data on polygenic mutation, chromosomal organization and morphological integration.Abstract:
A statistical genetic model of a multivariate phenotype is derived to investigate the covariation of pleiotropic mutations with additive effects under the combined action of phenotypic selection, linkage and the mating system. Equilibrium formulas for large, randomly mating populations demonstrate that, when selection on polygenic variation is much smaller than twice the harmonic mean recombination rate between loci with interacting fitnesses, linkage disequilibrium is negligible and pleiotropy is the main cause of genetic correlations between characters. Under these conditions, approximate expressions for the dynamics of the genetic covariances due to pleiotropic mutations are obtained. Patterns of genetic covariance between characters and their evolution are discussed with reference to data on polygenic mutation, chromosomal organization and morphological integration.read more
Citations
More filters
Journal ArticleDOI
The measurement of selection on correlated characters
Russell Lande,Stevan J. Arnold +1 more
TL;DR: Measures of directional and stabilizing selection on each of a set of phenotypically correlated characters are derived, retrospective, based on observed changes in the multivariate distribution of characters within a generation, not on the evolutionary response to selection.
Journal ArticleDOI
Quantitative genetic analysis of multivariate evolution, applied to brain:body size allometry.
TL;DR: Methods of multivariate analysis, functional analysis and optimality criteria popular among evolutionists, do not account for dynamical constraints imposed by the pattern of genetic variation within populations.
Journal ArticleDOI
Genotype-environment interaction and the evolution of phenotypic plasticity.
Sara Via,Russell Lande +1 more
TL;DR: These models utilize the statistical relationship which exists between genotype‐environment interaction and genetic correlation to describe evolution of the mean phenotype under soft and hard selection in coarse‐grained environments.
Journal ArticleDOI
Sexual dimorphism, sexual selection, and adaptation in polygenic characters.
TL;DR: Sexual dimorphism may result from natural and/or sexual selection, and systems of mating are often thought to evolve in response to ecological pressures, although mating preferences may be self-reinforcing.
Journal ArticleDOI
Perspective: complex adaptations and the evolution of evolvability
Günter P. Wagner,Lee Altenberg +1 more
TL;DR: It is proposed that the genotype‐phenotype map can evolve by two main routes: epistatic mutations, or the creation of new genes, a common result for organismic design is modularity.
References
More filters
Book
Evolution and the Genetics of Populations: Volume 2, The Theory of Gene Frequencies
Sewall Wright,Oscar Kempthorne +1 more
Journal ArticleDOI
The maintenance of genetic variability by mutation in a polygenic character with linked loci.
TL;DR: It is concluded that large amounts of genetic variation can be maintained by mutation in polygenic characters even when there is strong stabilizing selection.
Journal ArticleDOI
Mutation Rate and Dominance of Genes Affecting Viability in DROSOPHILA MELANOGASTER
TL;DR: That these mutants have a disproportionately large heterozygous effect on total fitness (as well as on the viability component thereof) is shown by the low ratio of the genetic load in equilibrium homozygote to that of new mutant homozygotes.
Journal ArticleDOI
The genetic structure of natural populations of drosophila melanogaster. i. spontaneous mutation rate of polygenes controlling viability.
Journal ArticleDOI
The Results of Crosses between Inbred Strains of Guinea Pigs, Differing in Number of Digits.
TL;DR: Strain D, in my possession, traces exclusively to 3 animals of this strain, kindly presented by Professor CASTLE in 1915, and may safely be assumed to be homozygous in most respects.