Journal ArticleDOI
The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity?
Tamara Y. Forbes-Hernandez,Massimiliano Gasparrini,Sadia Afrin,Stefano Bompadre,Bruno Mezzetti,José L. Quiles,Francesca Giampieri,Maurizio Battino +7 more
TLDR
The aim of this review is to update and discuss the molecular and cellular mechanisms proposed in recent studies to elucidate the healthy effects of strawberry polyphenols against the most common chronic diseases, such as cancer, cardiovascular diseases, metabolic syndrome, and inflammation.Abstract:
Current evidence indicates that the consumption of strawberries, a natural source of a wide range of nutritive and bioactive compounds, is associated with the prevention and improvement of chronic-degenerative diseases. Studies involving cells and animals provide evidence on the anti-inflammatory, anticarcinogenic and antiproliferative activity of the strawberry. Epidemiological and clinical studies demonstrate that its acute consumption increases plasma antioxidant capacity, improves circulating inflammatory markers and ameliorates postprandial glycemic response. At the same time, a protracted intake reduces chronic inflammation and improves plasma lipid profile, supporting cardiovascular health, especially in individuals with increased risk for metabolic syndrome. To explain these beneficial effects, much attention has been paid in the past to the antioxidant properties of strawberry polyphenols. However, recent research has shown that their biological and functional activities are related not only to the antioxidant capacity but also to the modulation of many cellular pathways involved in metabolism, survival, proliferation, and antioxidant defenses. The aim of this review is to update and discuss the molecular and cellular mechanisms proposed in recent studies to elucidate the healthy effects of strawberry polyphenols against the most common chronic diseases, such as cancer, cardiovascular diseases, metabolic syndrome, and inflammation.read more
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Dietary polyphenols and type 2 diabetes: Human Study and Clinical Trial.
Hui Cao,Hui Cao,Juanying Ou,Lei Chen,Yanbo Zhang,Tomasz Szkudelski,Dominique Delmas,Maria Daglia,Jianbo Xiao +8 more
TL;DR: This review summarizes human studies and clinical trials of polyphenols as anti-diabetic agents and indicates that individual flavonoid or isoflavonoid compounds appear to have no therapeutic effect on diabetes, based on the limited clinical data.
Journal ArticleDOI
Promising Health Benefits of the Strawberry: A Focus on Clinical Studies
Sadia Afrin,Massimiliano Gasparrini,Tamara Y. Forbes-Hernandez,Patricia Reboredo-Rodríguez,Patricia Reboredo-Rodríguez,Bruno Mezzetti,Alfonso Varela-López,Francesca Giampieri,Maurizio Battino,Maurizio Battino +9 more
TL;DR: The bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies.
Journal ArticleDOI
Relevance of functional foods in the Mediterranean diet: the role of olive oil, berries and honey in the prevention of cancer and cardiovascular diseases
Maurizio Battino,Tamara Y. Forbes-Hernandez,Massimiliano Gasparrini,Sadia Afrin,Danila Cianciosi,Jiaojiao Zhang,Piera Pia Manna,Patricia Reboredo-Rodríguez,Alfonso Varela Lopez,José L. Quiles,Bruno Mezzetti,Stefano Bompadre,Jianbo Xiao,Francesca Giampieri +13 more
TL;DR: The aim of this review is to present and discuss the recent evidence, obtained from in vitro, in vivo and epidemiological studies, on the potential roles exerted by these foods in the prevention and progression of different types of cancer and CVDs.
Journal ArticleDOI
Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade.
Francesca Giampieri,José M. Alvarez-Suarez,José M. Alvarez-Suarez,Mario D. Cordero,Massimiliano Gasparrini,Tamara Y. Forbes-Hernandez,Sadia Afrin,Celestino Santos-Buelga,Ana M. González-Paramás,Paola Astolfi,Corrado Rubini,Antonio Zizzi,Sara Tulipani,José L. Quiles,Bruno Mezzetti,Maurizio Battino,Maurizio Battino +16 more
TL;DR: Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.
Journal ArticleDOI
New Challenges for the Design of High Value Plant Products: Stabilization of Anthocyanins in Plant Vacuoles.
TL;DR: An overview of economically interesting plant species, both food crops and ornamentals, in which anthocyanin content was improved by traditional breeding or transgenesis is presented.
References
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Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2007 Update A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Wayne D. Rosamond,Katherine M. Flegal,Gary Friday,Karen L. Furie,Alan S. Go,Kurt J. Greenlund,Nancy Haase,Michael Ho,Virginia J. Howard,Bret Kissela,Steven J. Kittner,Donald M. Lloyd-Jones,Mary M. McDermott,James B. Meigs,Claudia S. Moy,Graham Nichol,Christopher J. O'Donnell,Véronique L. Roger,John S. Rumsfeld,Paul D. Sorlie,Julia Steinberger,Thomas Thom,Sylvia Wasserthiel-Smoller,Yuling Hong +23 more
TL;DR: This chapter describes the most important sources and the types of data the AHA uses from them and other government agencies to derive the annual statistics in this Update.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2008 Update A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Wayne Rosamond,Katherine M. Flegal,Karen L. Furie,Alan S. Go,Kurt J. Greenlund,Nancy Haase,Susan M. Hailpern,Michael Ho,Virginia J. Howard,Bret Kissela,Steven J. Kittner,Donald M. Lloyd-Jones,Mary M. McDermott,James B. Meigs,Claudia S. Moy,Graham Nichol,Christopher J. O'Donnell,Véronique L. Roger,Paul D. Sorlie,Julia Steinberger,Thomas Thom,Matthew Wilson,Yuling Hong +22 more
TL;DR: Each year the American Heart Association brings together the most up-to-date statistics on heart disease, stroke, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update.
Journal ArticleDOI
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Lawrence J. Appel,Thomas Burton Moore,Thomas Burton Moore,Eva Obarzanek,William M. Vollmer,Laura P. Svetkey,Frank M. Sacks,George A. Bray,Thomas M. Vogt,Jeffrey A. Cutler,Marlene M. Windhauser,Pao-Hwa Lin,Njeri Karanja,Denise G. Simons-Morton,Marjorie L. McCullough,Janis F. Swain,Priscilla Steele,Marguerite Evans,Edgar R. Miller,David W. Harsha +19 more
TL;DR: In this paper, the effects of dietary patterns on blood pressure were assessed in a clinical trial, Dietary Approaches to Stop Hypertension, where the subjects were fed a control diet that was low in fruits, vegetables, and dairy products, with a fat content typical of the average diet in the United States.