The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering.
TLDR
The potential role of mesenchymal stem cells in the following respects will be discussed: their contribution in continued root maturation in endodontically treated immature teeth with periradicular periodontitis or abscess and their potential utilization for pulp/dentin regeneration and bioroot engineering.Citations
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Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine
TL;DR: This article will review the isolation and characterization of the properties of different dental MSC-like populations in comparison with those of other MSCs, such as BMMSCs.
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Stem/Progenitor Cell–Mediated De Novo Regeneration of Dental Pulp with Newly Deposited Continuous Layer of Dentin in an In Vivo Model
George T.-J. Huang,Takayoshi Yamaza,Lonnie D. Shea,Farida Djouad,Nastaran Z. Kuhn,Rocky S. Tuan,Songtao Shi +6 more
TL;DR: This study provides the first evidence showing that pulp- like tissue can be regenerated de novo in emptied root canal space by stem cells from apical papilla and dental pulp stem cells that give rise to odontoblast-like cells producing dentin-like tissue on existing dentinal walls.
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Evaluation of the Delivery of Mesenchymal Stem Cells into the Root Canal Space of Necrotic Immature Teeth after Clinical Regenerative Endodontic Procedure
TL;DR: It is demonstrated that the evoked-bleeding step in regenerative procedures triggers the significant accumulation of undifferentiated stem cells into the canal space where these cells might contribute to the regeneration of pulpal tissues seen after antibiotic paste therapy of the immature tooth with pulpal necrosis.
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Histologic characterization of regenerated tissues in canal space after the revitalization/revascularization procedure of immature dog teeth with apical periodontitis.
TL;DR: These findings explained in part why many clinical cases of immature teeth with apical periodontitis or abscess may gain root thickness and apical length after conservative treatment with the revitalization procedure.
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Stem cells in dentistry – Part I: Stem cell sources
TL;DR: Oral tissues are expected to be not only a source but also a therapeutic target for stem cells, as stem cell and tissue engineering therapies in dentistry continue to attract increasing clinical interest.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
TL;DR: Postnatal human DPSCs are isolated that have the ability to form a dentin/pulp-like complex and are compared with human bone marrow stromal cells, known precursors of osteoblasts.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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Investigation of multipotent postnatal stem cells from human periodontal ligament
Byoung Moo Seo,Masako Miura,Stan Gronthos,P. M. Bartold,Sara Batouli,Jaime S. Brahim,M. F. Young,Pamela Gehron Robey,Cun-Yu Wang,Songtao Shi +9 more
TL;DR: It is suggested that PDL contains stem cells that have the potential to generate cementum/PDL-like tissue in vivo and transplantation of these cells might hold promise as a therapeutic approach for reconstruction of tissues destroyed by periodontal diseases.