Journal ArticleDOI
The Human Microbiome.
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This article is published in American Journal of Nursing.The article was published on 2017-09-01. It has received 643 citations till now. The article focuses on the topics: Microbiome & Human microbiome.read more
Citations
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Journal ArticleDOI
Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis
Jethro S. Johnson,Daniel Spakowicz,Bo-Young Hong,Lauren M. Petersen,Patrick Demkowicz,Lei Chen,Shana R. Leopold,Blake M. Hanson,Hanako O. Agresta,Mark Gerstein,Erica Sodergren,George M. Weinstock +11 more
TL;DR: The authors explore the potential of the 16S gene for discriminating bacterial taxa and show that full-length sequencing combined with appropriate clustering of intragenomic sequence variation can provide accurate representation of bacterial species in microbiome datasets.
Journal ArticleDOI
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Vancheswaran Gopalakrishnan,Beth A. Helmink,Christine N. Spencer,Alexandre Reuben,Jennifer A. Wargo +4 more
TL;DR: An understanding of the microbiome's influence on immune responses and cancer is key, and factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses are important.
Journal ArticleDOI
Scaling laws predict global microbial diversity
Kenneth J. Locey,Jay T. Lennon +1 more
TL;DR: A unified scaling law is shown that predicts the abundance of dominant species across 30 orders of magnitude to the scale of all microorganisms on Earth and predicts that Earth is home to as many as 1 trillion microbial species.
Journal ArticleDOI
Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity.
TL;DR: The ethnicity or population-specific variations in human microbiome composition, as reviewed in this report, question the universality of the microbiome-based therapeutic strategies and recommend for geographically tailored community-scale approaches to microbiome engineering.
Journal ArticleDOI
Gut microbiota imbalance and colorectal cancer.
Johan Gagnière,Jennifer Raisch,Julie Veziant,Nicolas Barnich,Richard Bonnet,Emmanuel Buc,Marie-Agnès Bringer,Denis Pezet,Mathilde Bonnet +8 more
TL;DR: The possible links between the bacterial microbiota and colorectal carcinogenesis are discussed, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial-derived metabolism, oxidative stress and anti-oxidative defenses modulation.
References
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Journal ArticleDOI
Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis
Jethro S. Johnson,Daniel Spakowicz,Bo-Young Hong,Lauren M. Petersen,Patrick Demkowicz,Lei Chen,Shana R. Leopold,Blake M. Hanson,Hanako O. Agresta,Mark Gerstein,Erica Sodergren,George M. Weinstock +11 more
TL;DR: The authors explore the potential of the 16S gene for discriminating bacterial taxa and show that full-length sequencing combined with appropriate clustering of intragenomic sequence variation can provide accurate representation of bacterial species in microbiome datasets.
Journal ArticleDOI
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Vancheswaran Gopalakrishnan,Beth A. Helmink,Christine N. Spencer,Alexandre Reuben,Jennifer A. Wargo +4 more
TL;DR: An understanding of the microbiome's influence on immune responses and cancer is key, and factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses are important.
Journal ArticleDOI
Scaling laws predict global microbial diversity
Kenneth J. Locey,Jay T. Lennon +1 more
TL;DR: A unified scaling law is shown that predicts the abundance of dominant species across 30 orders of magnitude to the scale of all microorganisms on Earth and predicts that Earth is home to as many as 1 trillion microbial species.
Journal ArticleDOI
Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity.
TL;DR: The ethnicity or population-specific variations in human microbiome composition, as reviewed in this report, question the universality of the microbiome-based therapeutic strategies and recommend for geographically tailored community-scale approaches to microbiome engineering.
Journal ArticleDOI
Gut microbiota imbalance and colorectal cancer.
Johan Gagnière,Jennifer Raisch,Julie Veziant,Nicolas Barnich,Richard Bonnet,Emmanuel Buc,Marie-Agnès Bringer,Denis Pezet,Mathilde Bonnet +8 more
TL;DR: The possible links between the bacterial microbiota and colorectal carcinogenesis are discussed, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial-derived metabolism, oxidative stress and anti-oxidative defenses modulation.