Open AccessJournal Article
The Immunoglobulin Nature of the Antigen Recognition Site on Cells Mediating Transplantation Immunity and Delayed Hypersensitivity
Sally Mason,Noel L. Warner +1 more
TLDR
Pretreatment of normal adult mouse spleen cells, or peritoneal exudate cells from mice sensitized to DNP~CSA with anti-immunoglobulin light polypeptide chain sera considerably suppressed the ability of these cells to induce the graft v8 host reaction or the transfer of delayed hypersensitivity.Abstract:
Summary Pretreatment of normal adult mouse spleen cells, or peritoneal exudate cells from mice sensitized to DNP~CSA, with anti-immunoglobulin light polypeptide chain sera considerably suppressed the ability of these cells to induce the graft v8 host reaction or the transfer of delayed hypersensitivity. Anti-heavy chain sera did not cause this suppression. These results indicate that the antigen recognition site on lymphocytes involves an immunoglobulin light chain which is either free or bound to a new heavy chain type.read more
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Transmembrane control of the receptors on normal and tumor cells: I. Cytoplasmic influence over cell surface components☆
Book ChapterDOI
The regulatory influence of activated T cells on B cell responses to antigen.
David H. Katz,Baruj Benacerraf +1 more
TL;DR: This chapter discusses the intimate mechanisms of the regulation of antibody responses by T cells, the significance of these phenomena for the regulatory processes of the immune system, and their possible implication for the pathogenesis of various immunopathological states.
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Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse splenic lymphocytes
TL;DR: The results, together with previous reports by others, suggest that IgM, in its monomeric form, is the main antigen-specific receptor on lymphocytes of normal mice.
Cell surface immunoglobulin ii. isolation and characterization of immunoglobulin
TL;DR: In this article, the proteins on surfaces of living splenic lymphocytes from normal BALB/c mice were iodinated enzymatically, and the Ig was recovered from the cell surface in the form of an IgM monomer.
Journal ArticleDOI
Isolation and partial characterization of lymphocyte surface immunoglobulins
TL;DR: Results provide direct evidence for the presence of immunoglobulins composed of light and heavy polypeptide chains on the surfaces of lymphocytes of all classes.