The impact of ageing on male reproductive success in Drosophila melanogaster
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TLDR
It is suggested that ejaculates of older males are less effective at inducing beneficial responses and that older male flies produce smaller or ill‐composed ejaculates, significantly affecting his reproductive success.About:
This article is published in Experimental Gerontology.The article was published on 2018-03-01 and is currently open access. It has received 34 citations till now. The article focuses on the topics: Sperm competition & Reproductive success.read more
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Journal ArticleDOI
Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable inDrosophila
Irem Sepil,Ben R. Hopkins,Ben R. Hopkins,Rebecca Dean,Eleanor Bath,Solomon Friedman,Ben Swanson,Harrison J. Ostridge,Harrison J. Ostridge,Lucy Harper,Lucy Harper,Norene A. Buehner,Mariana F. Wolfner,Rebecca Konietzny,Marie-Laëtitia Thézénas,Elizabeth Sandham,Philip D. Charles,Roman Fischer,Josefa Steinhauer,Benedikt M. Kessler,Stuart Wigby,Stuart Wigby,Stuart Wigby +22 more
TL;DR: It is demonstrated that seminal fluid deterioration contributes to male reproductive decline via mating-dependent mechanisms that include posttranslational modifications to seminal proteins and altered seminal proteome composition and transfer, and is found that lifespan-extending systemic down-regulation of insulin signaling results in improved late-life ejaculate performance, indicating simultaneous amelioration of both somatic and reproductive aging.
Journal ArticleDOI
Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress
Haixia Zhao,Na Ma,Zhaoqi Liu,Ting Wang,Chengfu Yuan,Yumin He,Yaoyan Dun,Zhou Zhiyong,Ding Yuan,Changcheng Zhang +9 more
TL;DR: Treatment with WZ for 4 months significantly increased the testicular weight and index, sperm count and viability, and the Levels of testosterone and decreased the levels of estradiol, and effectively improves ageing‐related testicular dysfunction through inhibition of germ cell apoptosis via ERS.
Journal ArticleDOI
Homeostatic maintenance and age-related functional decline in the Drosophila ear
Alyona Keder,Camille H. Tardieu,Liza Malong,Anastasia Filia,Assel Kashkenbayeva,Fay Newton,Marcos Georgiades,Jonathan E. Gale,Michael Lovett,Andrew P. Jarman,Joerg T. Albert +10 more
TL;DR: It is shown that Drosophila, just like humans, display ARHL and that adult-specific manipulation of homeostatic regulators in the fly’s auditory neurons accelerated - or protected against - ARHL.
Journal ArticleDOI
Social behavior and aging: A fly model.
Dova B Brenman-Suttner,Dova B Brenman-Suttner,Ryley T. Yost,Ariel K. Frame,J. Wesley Robinson,Amanda J. Moehring,Anne Simon +6 more
TL;DR: Recent advancements in behavioral genetics are discussed, with a focus on how studies in Drosophila melanogaster have provided insight into the effect of aging on aspects of social behavior, including across generations.
Journal ArticleDOI
Metabolic Rate and Oxygen Radical Levels Increase But Radical Generation Rate Decreases with Male Age in Drosophila melanogaster Sperm.
Biz R. Turnell,Klaus Reinhardt +1 more
TL;DR: Sperm from older males had higher mitochondrial ROS levels and a higher metabolic rate but produced ROS at a lower rate, which support the idea of a tissue-specific optimal rate of aerobic respiration balancing the production and removal of ROS, with aging causing a shift away from this optimum and leading to increased ROS accumulation.
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Related Papers (5)
Are old males still good males and can females tell the difference? Do hidden advantages of mating with old males off-set costs related to fertility, or are we missing something else?
Sheri L. Johnson,Neil J. Gemmell +1 more