Journal ArticleDOI
The lipid solubility of porphyrins modulates their phototoxicity in membrane models
Carla Emiliani,M. Delmelle +1 more
TLDR
In this article, the photosensitizing activities of hematoporphyrin, Cu-hematoporphrin, protoporphynin, Zn-protoporphin, deuteroporphrin and uroporphrin are studied.Abstract:
The photosensitizing activities of hematoporphyrin, Cu-hematoporphyrin, protoporphyrin. Zn-protoporphyrin, deuteroporphyrin and uroporphyrin are studied. The relative yields of 1O2 are measured in buffer (pH 8.0) and compared to the yields of Type II photodamages induced on cholesterol embedded in egg lecithin liposomes. Results show that the solubilization of the sensitizer in the lipid bilayer is a prerequisite for its photosensitizing activity at the membrane level. In this context, the partition coefficient represents an important parameter.read more
Citations
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Journal ArticleDOI
A Compilation of Singlet Oxygen Yields from Biologically Relevant Molecules
TL;DR: The purpose of this review was to compile data from many different sources to provide a convenient resource for biological scientists with interest in this area and is essentially an updated subset of the excellent comprehensive review on singlet oxygen yields by Wilkinson et af.
Journal ArticleDOI
Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes.
Isaac Antolín,Carmen Rodríguez,Rosa M. Sainz,Juan C. Mayo,Higinio Uría,Monica Lidia Kotler,María Josefa Rodríguez-Colunga,Deuo Tolivia,Armando Menendez-Pelaez +8 more
TL;DR: Results demonstrate that melatonin administration decreases the percentage of damaged cells, porphyrin synthesis, and aminolevulinate synthase (ALA‐S) mRNA levels and increases the mRNA levels for manganese superoxide‐dismutase and copper‐zinc superoxide dismutase.
Journal ArticleDOI
Oxygen consumption and diffusion effects in photodynamic therapy.
Thomas H. Foster,Richards S. Murant,Robert G. Bryant,Robert S. Knox,Scott L. Gibson,Russell Hilf +5 more
TL;DR: A mathematical model of the Type II mechanism of photooxidation is used to compute estimates of the rate of therapy-dependent in vivo oxygen depletion resulting from reactions of singlet oxygen (1O2) with intracellular substrate and suggests that the oxygen depletion could be partially overcome by fractionating the light delivery.
Journal ArticleDOI
Photomodification of biological membranes with emphasis on singlet oxygen mechanisms
TL;DR: The evidence clearly indicates that membrane photomodification cannot be understood based only on the properties of sensitizers and singlet oxygen in aqueous solution and in membranes.
Journal ArticleDOI
HEMATOPORPHYRIN and HPD: PHOTOPHYSICS, PHOTOCHEMISTRY and PHOTOTHERAPY
TL;DR: The topic of porphyrin photosensitization was reviewed in this Journal three years ago as part of a commentary on photodynamic dye action and a substantial amount of new literature has appeared during the intervening years.
References
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Journal Article
Photoradiation therapy for the treatment of malignant tumors
Thomas J. Dougherty,Jerome E. Kaufman,Abraham Goldfarb,Kenneth R. Weishaupt,Donn Boyle,Arnold Mittleman +5 more
TL;DR: Deep-seated and pigmented tumors required a higher dose of drug for effective treatment than did the more superficial and nonpigmented lesions, and a high therapeutic ratio between tumor and skin response has been obtained.
Book ChapterDOI
CHAPTER 3 – Photosensitized Oxidation and Singlet Oxygen: Consequences in Biological Systems
Journal ArticleDOI
New method of detecting singlet oxygen production
TL;DR: A new method for detecting the formation of singlet oxygen by the generation of stable nitroxide radicals from sterically hindered amines is reported.
Journal ArticleDOI
A new method for the detection of singlet oxygen in aqueous solutions
I. Kraljić,S. El Mohsni +1 more
TL;DR: In this article, the imidazole plus RNO method has been applied to a number of sensitizing and non-sensitizing dyes, which can be used as a sensitive and selective test for the presence of 1O2 in aqueous solutions.
Journal ArticleDOI
Detection of singlet oxygen production by ESR.
Johan Emelian Moan,Einar Wold +1 more
TL;DR: Investigation of the problem of how to detect 1O2 in neutral aqueous solutions involving the generation of stable nitroxide radicals when 2,2,6,6,-tetramethylpiperidin is found, found no radical production.