Isaac Antolín

TL;DR: This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes.

TL;DR: Results demonstrate that melatonin administration decreases the percentage of damaged cells, porphyrin synthesis, and aminolevulinate synthase (ALA‐S) mRNA levels and increases the mRNA levels for manganese superoxide‐dismutase and copper‐zinc superoxide dismutase.

TL;DR: Melatonin increases gene expression for antioxidant enzymes in rat brain cortex in a manner similar to that found in humans, according to Munksgaard et al. (1998).

TL;DR: Melatonin, at physiological serum concentrations, increases the mRNA of both superoxide dismutases (SODs) and glutathione peroxidase (GPx) in two neuronal cell lines and suggests that the regulation of AOE gene expression is likely to be receptor mediated.

TL;DR: Investigation of the possible contribution to radical scavenging by substituted kynuramines formed from melatonin via pyrrole ring cleavage finds that N1-Acetyl-5-methoxykynuramine may contribute to the antioxidant properties of the indolic precursor melatonin.