Journal ArticleDOI
The long-term psychobiological consequences of intermittent postnatal separation in the squirrel monkey
Seymour Levine,Tara Mody +1 more
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TLDR
Intermittent separation during infancy followed by reunion with the mother were shown to lead to a significant reduction in both the cortisol response and the response of the noradrenergic system following social isolation in juvenile squirrel monkeys at 2 and 3 years of age.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2003-01-01. It has received 100 citations till now. The article focuses on the topics: Squirrel monkey & Primate.read more
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Loneliness Matters: A Theoretical and Empirical Review of Consequences and Mechanisms
TL;DR: The features and consequences of loneliness are reviewed within a comprehensive theoretical framework that informs interventions to reduce loneliness and features of a loneliness regulatory loop are employed to explain cognitive, behavioral, and physiological consequences.
Journal ArticleDOI
Resilience as a dynamic concept.
TL;DR: Evidence on turning point effects associated with experiences that increase opportunities and enhance coping and Gene–environment interaction findings are considered, and it is noted that there is some evidence that the genetic influences concerns responsivity to all environments and not just bad ones.
Journal ArticleDOI
Social regulation of gene expression in human leukocytes
Steve W. Cole,Louise C. Hawkley,Jesusa M.G. Arevalo,Caroline Y. Sung,Robert M. Rose,John T. Cacioppo +5 more
TL;DR: In this article, the authors analyzed genome-wide transcriptional activity in people who chronically experienced high versus low levels of subjective social isolation (loneliness) to assess alterations in the activity of transcription control pathways that might contribute to increased adverse health outcomes in social isolates.
Journal ArticleDOI
Developmental determinants of sensitivity and resistance to stress
TL;DR: The issue of the definition of stress is revisited to highlight the difficulties with the contemporary definitions and the literature on the influence of early experiences on the endocrine stress responses and behavior in rodents, sub-human primates and humans is reviewed.
Journal ArticleDOI
Annual Research Review: Resilience--Clinical Implications.
TL;DR: Resilience findings do not translate into a clear programme of prevention and treatment, but they do provide numerous leads that focus on the dynamic view of what may be involved in overcoming seriously adverse experiences.
References
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Journal ArticleDOI
Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress
Dong Liu,Josie Diorio,Josie Diorio,Beth Tannenbaum,Beth Tannenbaum,Christian Caldji,Christian Caldji,Darlene D. Francis,Darlene D. Francis,Alison Freedman,Alison Freedman,Shakti Sharma,Shakti Sharma,Deborah Pearson,Deborah Pearson,Paul M. Plotsky,Paul M. Plotsky,Michael J. Meaney,Michael J. Meaney +18 more
TL;DR: It is suggested that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.
Journal ArticleDOI
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
TL;DR: Rat pups 2-14 days of age were exposed daily to handling, maternal separation, or were left entirely undisturbed (non-handled; NH), while as adults, MS rats showed increased hypothalamic corticotropin-releasing factor (CRF) mRNA levels compared with NH rats, while CRF mRNA levels in H rats were significantly lower than either MS or NH animals.
Journal ArticleDOI
Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models.
TL;DR: Increasing evidence supports the view that the interaction of perinatal exposure to adversity with individual genetic liabilities may increase an individual's vulnerability to the expression of psycho- and physiopathology throughout life.
Journal ArticleDOI
Low cortisol and a flattening of expected daytime rhythm: potential indices of risk in human development.
Megan R. Gunnar,Delia M. Vazquez +1 more
TL;DR: It is argued that developmental studies are needed that help explicate the origins of low cortisol and to determine whether the development of hypocortisolism is, in fact, preceded by periods of frequent or chronic activation of the LHPA axis, and that developmental researchers who incorporate measures of salivary cortisol into their studies of at-risk populations need to be aware of the hypocORTisolism phenomenon.
Journal ArticleDOI
Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse
TL;DR: Abused women without major depressive disorder exhibited greater than usual ACTH responses to CRF administration, whereas abused women with major de...
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