Journal ArticleDOI
The neurobiology of sexual function.
TLDR
The influence of endocrine, neurotransmitter, and central nervous system influences on male and female sexual function are discussed for sexual desire, arousal, and orgasm or ejaculation stages of sexual responding.Abstract:
This article provides a review of the past and current literature on the neurobiology of sexual function. The influence of endocrine, neurotransmitter, and central nervous system influences on male and female sexual function are discussed for sexual desire, arousal, and orgasm or ejaculation stages of sexual responding. Endocrine factors reviewed include the following: androgens, estrogens, progesterone, prolactin, oxytocin, cortisol, and pheromones. Neurotransmitters and neuropeptides discussed include nitric oxide, serotonin, dopamine, epinephrine, norepinephrine, opioids, acetylcholine, histamine, and γ-aminobutyric acid. Central nervous system influences on sexual function are discussed briefly with reference to brainstem regions, the hypothalamus, and the forebrain.read more
Citations
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Journal ArticleDOI
Hypersexual Disorder: A Proposed Diagnosis for DSM-V
TL;DR: Specific polythetic diagnostic criteria, as well as behavioral specifiers, are proposed, intended to integrate empirically based contributions from various putative pathophysiological perspectives, including dysregulation of sexual arousal and desire, sexual impulsivity, sexual addiction, and sexual compulsivity.
Journal ArticleDOI
Is There a Gender Difference in Strength of Sex Drive? Theoretical Views, Conceptual Distinctions, and a Review of Relevant Evidence
TL;DR: For instance, this paper found that men have more frequent and more intense sexual desires than women, as reflected in spontaneous thoughts about sex, frequency and variety of sexual fantasies, desired frequency of intercourse, desired number of partners, masturbation, willingness to forego sex, initiating versus refusing sex, making sacrifices for sex, and other measures.
Journal ArticleDOI
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application.
TL;DR: A diversity of multi-target strategies are proposed for the more efficacious and rapid control of core and co-morbid symptoms of depression, together with improved tolerance relative to currently available agents.
Journal ArticleDOI
Ecological effects of pharmaceuticals in aquatic systems--impacts through behavioural alterations.
TL;DR: It is demonstrated that prey consumption can be an important exposure route as on average 46% of the pharmaceutical in ingested prey accumulated in the predator, suggesting that investigations of exposure through bioconcentration, where trophic interactions and subsequent bioaccumulation of exposed individuals are ignored, underestimate exposure.
Book
Emotion and decision making explained
TL;DR: In this article, the authors seek explanations of emotion and decision-making by considering the relation between emotion, and reward value, and subjective feelings of pleasure, and how the brain implements decision making, and are gene-defined rewards and emotions in the interests of the genes, and does rational multistep planning enable us to go beyond selfish genes to long-term plans and social contracts in the interest of the individual.
References
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Book
The Physiology of Reproduction
Ernst Knobil,J. D. Neill +1 more
TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
Book
Human Sexual Response
TL;DR: A report on clinical findings about human sexual response patterns and orgasmic expression was published in this article, which showed that human sexual responses are correlated with the number of orgasms and sexual arousal.
Journal ArticleDOI
Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group.
Irwin Goldstein,Tom F. Lue,Harin Padma-Nathan,Raymond C. Rosen,William D. Steers,Pierre A. Wicker +5 more
TL;DR: Oral sildenafil is an effective, well-tolerated treatment for men with erectile dysfunction and is associated with improved erectile function in the dose-response study.
Journal ArticleDOI
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
TL;DR: This article reviews many of the more important aspects about the structure, cellular localization, and regulation of each family of phosphodiesterases and places particular emphasis on new information obtained in the last few years about how differential expression andregulation of individual phosphodiesters relate to their function(s) in the body.
Journal ArticleDOI
Risperidone in the treatment of schizophrenia.
TL;DR: The results indicate that the optimal daily dose of risperidone for most schizophrenic patients in this study was 6 mg; this dose was as effective as 16 mg, and the incidence of extrapyramidal symptoms in patients receiving 6 mg of ris peridone was no higher than that in Patients receiving placebo.