The neutral theory of molecular evolution.
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It is stated that these sequences differed in the cytochromes c of various species to an extent that seemed unnecessary from the standpoint of their function.Abstract:
IN 1966, I became interested in the amino acid sequences of cytochrome c molecules ([Jukes 1966][1]). I noted that these sequences differed in the cytochromes c of various species to an extent that seemed unnecessary from the standpoint of their function. I stated, “The changes produced inread more
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Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.
TL;DR: A new statistical method for estimating divergence dates of species from DNA sequence data by a molecular clock approach is developed, and this dating may pose a problem for the widely believed hypothesis that the bipedal creatureAustralopithecus afarensis, which lived some 3.7 million years ago, was ancestral to man and evolved after the human-ape splitting.
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MUSCLE: a multiple sequence alignment method with reduced time and space complexity
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A general framework for estimating the relative pathogenicity of human genetic variants
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Adaptive versus non‐adaptive phenotypic plasticity and the potential for contemporary adaptation in new environments
TL;DR: It is concluded that adaptive plasticity that places populations close enough to a new phenotypic optimum for directional selection to act is the only Plasticity that predictably enhances fitness and is most likely to facilitate adaptive evolution on ecological time-scales in new environments.
References
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Evolutionary Rate at the Molecular Level
TL;DR: Calculating the rate of evolution in terms of nucleotide substitutions seems to give a value so high that many of the mutations involved must be neutral ones.
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Non-Darwinian Evolution
Jack Lester King,Thomas H. Jukes +1 more
TL;DR: NonDarwinian evolution of protein and DNA, comparing expectations of evolution models for protein and amino acid changes is compared.
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The nearly neutral theory of molecular evolution
TL;DR: The neutral mutation-random drift hypothesis put forward by Kimura (47) in 1968 provoked much controversy because this theory was contrary to the neo-Darwinian view at that time, and a complete review of the theory is found.
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Slightly deleterious mutant substitutions in evolution.
TL;DR: If this class of mutant substitution is important, it can be predicted that the evolution is rapid in small populations or at the time of speciation5.