Journal ArticleDOI
Non-Darwinian Evolution
Jack Lester King,Thomas H. Jukes +1 more
TLDR
NonDarwinian evolution of protein and DNA, comparing expectations of evolution models for protein and amino acid changes is compared.Abstract:
NonDarwinian evolution of protein and DNA, comparing expectations of evolution models for protein and amino acid changesread more
Citations
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A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.
TL;DR: Some examples were worked out using reported globin sequences to show that synonymous substitutions occur at much higher rates than amino acid-altering substitutions in evolution.
Journal ArticleDOI
Genetic distance between populations
TL;DR: If enough data are available, genetic distance between any pair of organisms can be measured in terms of D, and this measure is applicable to any kind of organism without regard to ploidy or mating scheme.
Journal ArticleDOI
Toward Defining the Course of Evolution: Minimum Change for a Specific Tree Topology
TL;DR: A method is presented that is asserted to provide all hypothetical ancestral character states that are consistent with describing the descent of the present-day character states in a minimum number of changes of state using a predetermined phylogenetic relationship among the taxa represented.
Journal ArticleDOI
Selforganization of matter and the evolution of biological macromolecules
TL;DR: The causes and effect of cause and effect, and the prerequisites of Selforganization, are explained in more detail in the I.IA.
Journal ArticleDOI
The neutral theory of molecular evolution.
TL;DR: It is stated that these sequences differed in the cytochromes c of various species to an extent that seemed unnecessary from the standpoint of their function.
References
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Journal ArticleDOI
Evolutionary Rate at the Molecular Level
TL;DR: Calculating the rate of evolution in terms of nucleotide substitutions seems to give a value so high that many of the mutations involved must be neutral ones.
Journal ArticleDOI
Repeated Sequences in DNA
Roy J. Britten,D. E. Kohne +1 more
TL;DR: Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms and used in medicine, science, and engineering.
Journal ArticleDOI
A Mathematical Theory of Natural and Artificial Selection, Part V: Selection and Mutation
TL;DR: This work shall first consider initial conditions, when only a few of the new type exist as the result of a single mutation; and then the course of events in a population where the new factor is present in such numbers as to be in no danger of extinction by mere bad luck.
Journal ArticleDOI
Enzymatic Synthesis of Deoxyribonucleic Acid. VIII. Frequencies of Nearest Neighbor Base Sequences in Deoxyribonucleic Acid
TL;DR: In the studies to be reported here, the frequencies of the 16 possible nearest neighbor pairs in a variety of DNA’s are derived by the technique of enzymatic incorporation of 5'-Pazlabeled nucleotides into DNA and then degradation of the DNA into 3’-nucleotides.
Journal ArticleDOI
Diffusion models in population genetics
TL;DR: Population genetics is that branch of genetics, whose object is the study of the genetical make-up of natural populations, by investigating the laws which govern the genetic structure ofnatural populations to clarify the mechanism of evolution.