Journal ArticleDOI
The Obsessive Compulsive Drinking Scale: A New Method of Assessing Outcome in Alcoholism Treatment Studies
TLDR
The OCDS scores appear to be sensitive to alcoholism severity and change during abstinence and relapse drinking, and its ease of use, reliability, validity, and analytic capabilities support its utility as a tool to measure severity and improvement during alcoholism treatment trials.Abstract:
Background: The 14-item Obsessive Compulsive Drinking Scale (OCDS) is a quick and reliable self-rating instrument that provides a total and two subscale scores that measure some cognitive aspects of alcohol "craving." This study validated further its utility as an alcoholism severity and treatment outcome instrument. Methods: Alcoholism severity and analogue craving scales were administered at baseline, and the OCDS was given at baseline and weekly to 41 alcohol-dependent individuals who participated in a 12-week pharmacologic and cognitive-behavioral treatment trial. Repeated-measures analysis of variance was used to examine group differences in the OCDS scores of those individuals who remained abstinent or drank during the trial. Results: At baseline, the OCDS was correlated with the alcohol composite score of the addiction severity index (r=.48), the alcohol dependence scale (r=.42), the analogue craving measures (range r=.40 to.57), and prestudy alcohol consumption (r=.60). Most importantly, the OCDS total and subscale scores were significantly different between individuals who had relapse drinking, who had "slip" drinking, and who remained abstinent, with relapsers showing the highest scores. Conclusions: The OCDS scores appear to be sensitive to alcoholism severity and change during abstinence and relapse drinking. Since the shared variance with analogue craving measures is only about 20% to 30%, it appears to be measuring a largely independent dimension of alcohol dependence. Its ease of use (5 minutes per self-rating), reliability, validity, and analytic capabilities support its utility as a tool to measure severity and improvement during alcoholism treatment trials.read more
Citations
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Journal ArticleDOI
Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence: The COMBINE Study: A Randomized Controlled Trial
Raymond F. Anton,Stephanie S. O'Malley,Domenic A. Ciraulo,Ron A. Cisler,David Couper,Dennis M. Donovan,David R. Gastfriend,James D. Hosking,Bankole A. Johnson,Joseph S. LoCastro,Richard Longabaugh,Barbara J. Mason,Margaret E. Mattson,William R. Miller,Helen M. Pettinati,Carrie L. Randall,Robert M. Swift,Roger D. Weiss,Lauren D. Williams,Allen Zweben +19 more
TL;DR: Patients receiving medical management with naltrexone, CBI, or both fared better on drinking outcomes, whereas acamprosate showed no evidence of efficacy, with or without CBI.
Book
Recent Developments in Alcoholism
TL;DR: The chapter will discuss the genetic epidemiology of alcoholism in women, with evidence presented that suggests the existence of two forms of Alcoholism in women: one more environmentally determined and one more influenced by genetic mediation.
Journal ArticleDOI
Psychometric Properties of the Penn Alcohol Craving Scale
TL;DR: The PACS is a reliable and valid measure of alcohol craving and can predict which individuals are at risk for subsequent relapse and had good discriminant validity.
Journal ArticleDOI
Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving
Hugh Myrick,Raymond F. Anton,Xingbao Li,Scott Henderson,Scott Henderson,David J. Drobes,Konstantin Voronin,Mark S. George,Mark S. George +8 more
TL;DR: It is suggested that alcoholics and not social drinkers, when exposed to alcohol cues, have increased brain activity in areas that reportedly subserve craving for other addictive substances.
Journal ArticleDOI
An evaluation of μ-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the combined pharmacotherapies and behavioral interventions for alcohol dependence (COMBINE) study
Raymond F. Anton,Gabor Oroszi,Stephanie S. O'Malley,David Couper,Robert M. Swift,Helen M. Pettinati,David Goldman +6 more
TL;DR: The results confirm and extend the observation that the functionally significant OPRM1 Asp40 allele predicts naltrexone treatment response in alcoholic individuals.
References
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