Journal ArticleDOI
The physical properties of an effective lung surfactant
TLDR
It is suggested that the phospholipids at the alveolar/air interface exhibit both thermodynamic (equilibrium) and kinetic forces during the course of a respiratory cycle.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1979-06-21. It has received 240 citations till now. The article focuses on the topics: Pulmonary surfactant.read more
Citations
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Journal ArticleDOI
Physical principles of membrane organization.
TL;DR: An understanding of the physical principles that govern the molecular organization of membranes is essential for an understanding of their physiological roles since structure and function are much more interdependent in membranes than in, say, simple chemical reactions in solution.
Journal ArticleDOI
Current perspectives in pulmonary surfactant--inhibition, enhancement and evaluation.
Yi Y. Zuo,Ruud A. W. Veldhuizen,A. Wilhelm Neumann,Nils O. Petersen,Nils O. Petersen,Fred Possmayer,Fred Possmayer +6 more
TL;DR: A better understanding of the biophysical properties of functional and dysfunctional PS is important for the further development of surfactant therapy, especially for its potential application in ARDS.
Journal ArticleDOI
Protein-lipid interactions and surface activity in the pulmonary surfactant system.
TL;DR: The present review summarizes the current knowledge on the structure, disposition and lipid-protein interactions of the hydrophobic surfactant proteins SP-B and SP-C, the two main actors participating in the surface properties of pulmonary Surfactant.
Journal ArticleDOI
The proteins of the surfactant system
TL;DR: In babies with respiratory distress syndrome, the clinical response to treatment with surfactant containing SP-B and SP-C is much faster than in babies treated with protein-free synthetic surfactants.
Journal ArticleDOI
Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films.
Elisa Parra,Jesús Pérez-Gil +1 more
TL;DR: The goal of the present review is to summarize current knowledge regarding the structure, lipid-protein interactions and mechanical features of surfactant membranes and films and how these properties correlate with surfactants biological function inside the lungs.
References
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Book ChapterDOI
The Physical State of Phospholipids and Cholesterol in Monolayers, Bilayers, and Membranes
Journal ArticleDOI
The formation of phosphatidylglycerol and other phospholipids by the transferase activity of phospholipase D.
TL;DR: Water-soluble alcohols can markedly stimulate the liberation of choline from ultrasonically treated lecithin by phospholipase D, usually due to an increase in hydrolase activity although often the associated transferase activity contributes.