The Preparation of Optically Active α-C-Substituted Glutamic Acid
Reads0
Chats0
TLDR
In this paper, the optical resolution of DL-2-methylglutamic acid has been performed using brucine as a resolving reagent; the two optically active isomers have been obtained.Abstract:
1) The optical resolution of DL-2-methylglutamic acid has been performed using brucine as a resolving reagent; the two optically active isomers have been obtained. 2) DL-2-Benzylglutamic acid has been synthesized using benzyl cyanide and diethyl succinate as the starting materials. Moreover, the optical resolution of this amino acid has been performed using strychinine as a resolving reagent. The two optically active isomers were obtained.read more
Citations
More filters
Journal ArticleDOI
Stereoselective synthesis of quaternary α-amino acids. Part 1: Acyclic compounds
Journal ArticleDOI
Enantioselektive α‐Alkylierung von Asparagin‐ und Glutaminsäure über die Dilithium‐enolatocarboxylate von 2‐[3‐Benzoyl‐2‐(tert‐butyl)‐1‐methyl‐5‐oxoimidazolidin‐4‐yl]essigsäure und 3‐[3‐Benzoyl‐2‐(tert‐butyl)‐1‐methyl‐5‐oxoimidazolidin‐4‐yl]propionsäure
Johannes Aebi,Dieter Seebach +1 more
TL;DR: The pure methyl esters of the heterocyclic carboxylic acids specified in the title were prepared in several steps by known methods from aspartic and glutamic acid, with overall yields of ca. 20%.
Journal ArticleDOI
Enantioselective Allylation of Nitro Group-Stabilized Carbanions Catalyzed by Chiral Crown Ether Phosphine−Palladium Complexes
TL;DR: In this article, an allylation of α-nitro ketones with allyl acetate was carried out in the presence of 2 equiv of alkali metal fluorides (KF, RbF, CsF) and 1 mol % of palladium catalysts prepared in situ from Pd2(dba)3·CHCl3 and chiral phosphine ligands.
Journal ArticleDOI
Effect of various analogues of D-glutamic acid on the D-glutamate-adding enzyme from Escherichis coli
Flore Pratviel-Sosa,Francine Acher,François Trigalo,Didier Blanot,Robert Azerad,Jean van Heijenoort +5 more
TL;DR: Twenty-four analogues of D-glutamic acid were tested as substrates or inhibitors of the D- glutamate-adding enzyme from Escherichia coli, and none of the examined compounds significantly inhibited the addition of radioactive D- Glutamic Acid to UDP-N-acetylmuramyl-L-alanine.
Journal ArticleDOI
Stereochemistry of reactions catalyzed by glutamate decarboxylase.
TL;DR: Decarboxylation of L-alpha-methylglutamic acid by this enzyme produced levorotatory gamma-aminovaleric acid and thus also occurs with retention of configuration.
References
More filters
Journal ArticleDOI
Optical Enantiomorphs of Isovaline
Journal ArticleDOI
The Syntheses from Levulinic Acid. A Possible Use of Some 2-Methyl-5-oxopyrrolidine-2-carboxylic Esters as Plasticizers
Tadao Takenishi,Osamu Simamura +1 more
TL;DR: The synthesis of 2-amino-2-methylglutaric acid from levulinic acid by Strecker's method was reported in this article, which gave 2-methyl-5-oxopyrrolidine-2carboxylic acid on dehydration, and some of its esters were prepared and tested for plasticizer performance.