Journal ArticleDOI
The REAL (REctal Anastomotic Leak) score for prediction of anastomotic leak after rectal cancer surgery
Alberto Arezzo,Marco Migliore,P. Chiaro,Simone Arolfo,Claudia Filippini,D. Di Cuonzo,Roberto Cirocchi,Mario Morino +7 more
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TLDR
This nomogram based on preoperative risk factors may assist surgeons in decision making to minimize risk by either not restoring bowel continuity or protecting the anastomosis with a temporary diverting stoma.Abstract:
Anastomotic leak after rectal cancer surgery is a severe complication associated with poorer oncologic outcome and quality of life. Preoperative assessment of the risk for anastomotic leak is a key component of surgical planning, including the opportunity to create a defunctioning stoma. The purpose of this study was to identify and quantify the risk factors for anastomotic leak to minimize risk by either not restoring bowel continuity or protecting the anastomosis with a temporary diverting stoma. Potentially relevant studies were identified from the following databases: PubMed, Embase and Cochrane Library. This meta-analysis included studies on transabdominal resection for rectal cancer that reported data about anastomotic leak. The risk for anastomotic leak after rectal cancer surgery was investigated. Preoperative, intraoperative, and postoperative factors were extracted and used to compare anastomotic leak rates. All variables demonstrating a p value 0.0791 to identify anastomotic leak were 79.1% and 32.9%, respectively. Accuracy of the threshold value was confirmed in the validation set with 77.8% sensitivity and 35.2% specificity. We trust that, with further refinement using prospective data, this nomogram based on preoperative risk factors may assist surgeons in decision making. The score is now available online (
http://www.real-score.org
).read more
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Intraoperative use of fluorescence with indocyanine green reduces anastomotic leak rates in rectal cancer surgery: an individual participant data analysis
Alberto Arezzo,Marco Augusto Bonino,Frédéric Ris,Luigi Boni,Elisa Cassinotti,Dominic Chi-Chung Foo,Nga Fan Shum,Alberto Brolese,Francesco Antonio Ciarleglio,Deborah S. Keller,Riccardo Rosati,Paola De Nardi,Ugo Elmore,Uberto Fumagalli Romario,Mehraneh D. Jafari,Alessio Pigazzi,E. G. Rybakov,M V Alekseev,Jun Watanabe,Nereo Vettoretto,Roberto Cirocchi,Roberto Passera,Edoardo Forcignanò,Mario Morino +23 more
TL;DR: Fluorescence imaging significantly reduced the incidence of AL (OR 0.341; 95% CI 0.220–0.530; p < 0.001), independent of age, gender, BMI, tumour and anastomotic distance from the anal verge and neoadjuvant therapy.
Journal ArticleDOI
Italian multi-society modified Delphi consensus on the definition and management of anastomotic leakage in colorectal surgery
Antonino Spinelli,Gabriele Anania,Alberto Arezzo,S. Berti,Francesco Bianco,Paolo Bianchi,Maurizio De Giuli,Paola De Nardi,Paolo De Paolis,Caterina Foppa,Mario Guerrieri,Pierluigi Marini,Roberto Persiani,Diego Piazza,Gilberto Poggioli,Salvatore Pucciarelli,Domenico D'Ugo,Adolfo Renzi,Francesco Selvaggi,Gianfranco Silecchia,Marco Montorsi +20 more
TL;DR: This Delphi survey identified items that expert colorectal surgeons agreed were important to be applied in the prevention, diagnosis, and management of AL, which represents the first consensus involving all relevant national scientific societies.
Journal ArticleDOI
Anastomotic leak and cancer-specific outcomes after curative rectal cancer surgery: a systematic review and meta-analysis.
TL;DR: AL may negatively impact cancer-specific outcomes after curative rectal cancer surgery and could be considered an independent negative prognostic factor.
Journal ArticleDOI
The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review.
Annamaria Agnes,Annamaria Agnes,Caterina Puccioni,Domenico D'Ugo,Domenico D'Ugo,Antonio Gasbarrini,Antonio Gasbarrini,Alberto Biondi,Alberto Biondi,Roberto Persiani,Roberto Persiani +10 more
TL;DR: The role of the gut microbiota in colorectal surgery complications was investigated in this article, where the authors found that the GM composition during and after surgery can influence the outcome of the surgery.
Journal ArticleDOI
Intra‐operative fluorescence angiography is reproducible and reduces the rate of anastomotic leak after colorectal resection for cancer: a prospective case‐matched study
Marina Wojcik,Alexandre Doussot,Simone Manfredelli,Côme Duclos,Brice Paquette,Célia Turco,Bruno Heyd,Zaher Lakkis +7 more
TL;DR: Intra‐operative fluorescence angiography (IOFA) with indocyanine green provides information on tissue perfusion that may help prevent an anastomotic leak (AL) after left‐sided colonic or low anterior resection with anastsomosis for colorectal cancer.
References
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Multiple imputation of discrete and continuous data by fully conditional specification
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